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    THY-2 thymidylate synthase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829609, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THY-2
    Official Full Name
    thymidylate synthase 2
    Primary source
    TAIR:AT4G34570
    Locus tag
    AT4G34570
    See related
    Araport:AT4G34570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE; T4L20.150; T4L20_150; thymidylate synthase 2
    Summary
    Encodes a bifunctional dihydrofolate reductase - thymidylate synthase gene. This is unique in Arabidopsis and protozoa. Other organisms have independent genes for this function.
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    Genomic context

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    See THY-2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (16510933..16514372, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene F-box protein Neighboring gene Ribosomal protein S25 family protein Neighboring gene uncharacterized protein Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene G-box binding factor 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance. Corral MG, et al. Plant J, 2018 Jun 7. PMID 29876984
    2. The origin of the bifunctional dihydrofolate reductase-thymidylate synthase isogenes of Arabidopsis thaliana. Lazar G, et al. Plant J, 1993 May. PMID 8374616
    3. Distinctive features and differential regulation of the DRTS genes of Arabidopsis thaliana. Maniga A, et al. PLoS One, 2017. PMID 28594957, Free PMC Article
    4. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342289.1
    NM_001342291.1
    NM_001342292.1
    NM_119623.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dihydrofolate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydrofolate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrofolate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables thymidylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within 10-formyltetrahydrofolate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in dTMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thymidylate synthase 2
    NP_195183.2
    • thymidylate synthase 2 (THY-2); CONTAINS InterPro DOMAIN/s: Thymidylate synthase, active site (InterPro:IPR020940), Dihydrofolate reductase domain (InterPro:IPR001796), Dihydrofolate reductase conserved site (InterPro:IPR017925), Bifunctional dihydrofolate reductase/thymidylate synthase (InterPro:IPR012262), Thymidylate synthase (InterPro:IPR000398); BEST Arabidopsis thaliana protein match is: thymidylate synthase 1 (TAIR:AT2G16370.1); Has 13567 Blast hits to 13544 proteins in 2627 species: Archae - 73; Bacteria - 8801; Metazoa - 517; Fungi - 428; Plants - 92; Viruses - 256; Other Eukaryotes - 3400 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16510933..16514372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342290.1 → NP_001328948.1  thymidylate synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B676, A0A654FVG7, A0A7G2F3A3
      Conserved Domains (1) summary
      PTZ00164
      Location:14 → 518
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional

    2. NM_119623.5 → NP_195183.2  thymidylate synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05763, Q0WT35
      UniProtKB/TrEMBL
      A0A178UZ11, A0A5S9XYM0, A0A654FVG7
      Conserved Domains (1) summary
      PTZ00164
      Location:61 → 565
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional

    3. NM_001342289.1 → NP_001328947.1  thymidylate synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B685
      Conserved Domains (1) summary
      PTZ00164
      Location:61 → 397
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional

    4. NM_001342291.1 → NP_001328949.1  thymidylate synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B679, A0A654FVG7
      Conserved Domains (1) summary
      PTZ00164
      Location:36 → 540
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional

    5. NM_001342292.1 → NP_001328950.1  thymidylate synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B676, A0A654FVG7, A0A7G2F3A3
      Conserved Domains (1) summary
      PTZ00164
      Location:14 → 518
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05763.2

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