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    CER4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829521, updated on 22-Aug-2024

    Summary

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    Official Symbol
    CER4
    Primary source
    Araport:AT4G33790
    Locus tag
    AT4G33790
    See related
    TAIR:AT4G33790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ECERIFERUM 4; FAR3; FATTY ACID REDUCTASE 3; G7
    Summary
    Encodes an alcohol-forming fatty acyl-CoA reductase, involved in cuticular wax biosynthesis. Lines carrying recessive mutations are deficient in primary alcohol and have glossy stem surfaces.
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    Genomic context

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    See CER4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (16204096..16207956, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP phosphoribosyltransferase regulatory subunit Neighboring gene uncharacterized protein Neighboring gene Glycosyl hydrolase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CER4 encodes an alcohol-forming fatty acyl-coenzyme A reductase involved in cuticular wax production in Arabidopsis. Rowland O, et al. Plant Physiol, 2006 Nov. PMID 16980563, Free PMC Article
    2. Chrysotile asbestos and health in Zimbabwe: I. Analysis of miners and millers compensated for asbestos-related diseases since independence (1980). Cullen MR, et al. Am J Ind Med, 1991. PMID 1847001
    3. Functional expression of five Arabidopsis fatty acyl-CoA reductase genes in Escherichia coli. Doan TT, et al. J Plant Physiol, 2009 May 15. PMID 19062129
    4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342233.1
    NM_119537.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Jojoba acyl CoA reductase-related male sterility protein
    NP_567936.5
    • ECERIFERUM 4 (CER4); FUNCTIONS IN: oxidoreductase activity, acting on the CH-CH group of donors, fatty-acyl-CoA reductase (alcohol-forming) activity; INVOLVED IN: microsporogenesis, wax biosynthetic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Male sterility (InterPro:IPR004262), NAD(P)-binding domain (InterPro:IPR016040), Male sterility, NAD-binding (InterPro:IPR013120); BEST Arabidopsis thaliana protein match is: fatty acid reductase 1 (TAIR:AT5G22500.1); Has 2106 Blast hits to 2074 proteins in 384 species: Archae - 24; Bacteria - 471; Metazoa - 997; Fungi - 134; Plants - 291; Viruses - 0; Other Eukaryotes - 189 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16204096..16207956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119537.7 → NP_567936.5  Jojoba acyl CoA reductase-related male sterility protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567936.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81895, Q93ZB9, Q9M071
      UniProtKB/TrEMBL
      A0A178V2G4, A0A5S9XYD2
      Conserved Domains (1) summary
      PLN02996
      Location:6 → 493
      PLN02996; fatty acyl-CoA reductase

    2. NM_001342233.1 → NP_001329220.1  Jojoba acyl CoA reductase-related male sterility protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3Q9, A0A1P8B726
      Conserved Domains (1) summary
      PLN02996
      Location:1 → 380
      PLN02996; fatty acyl-CoA reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93ZB9.1

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