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    PRHA pathogenesis related homeodomain protein A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829117, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRHA
    Official Full Name
    pathogenesis related homeodomain protein A
    Primary source
    TAIR:AT4G29940
    Locus tag
    AT4G29940
    See related
    Araport:AT4G29940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F27B13.180; F27B13_180; HOMEODOMAIN PROTEIN; pathogenesis related homeodomain protein A; pathogenesis related homeodomain protein A
    Summary
    Homeodomain protein (PRHA). Expression of the gene differs in various vegetative and floral plant tissues and is positively influenced by the phytohormone auxin. It is often associated with regions of developing vascular tissue. The prha promoter is highly responsive to the synthetic auxin, naphthalene acetic acid, in transient assays using tobacco protoplasts. The PRHA protein has the capacity to bind to TAATTG core sequence elements but requires additional adjacent bases for high-affinity binding.
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    Genomic context

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    See PRHA in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Sequence:
    Chromosome: 4; NC_003075.7 (14648138..14653489, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Ypt/Rab-GAP domain of gyp1p superfamily protein Neighboring gene uncharacterized protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental and auxin-induced expression of the Arabidopsis prha homeobox gene. Plesch G, et al. Plant J, 1997 Sep. PMID 9351248
    2. Isolation of putative plant transcriptional coactivators using a modified two-hybrid system incorporating a GFP reporter gene. Cormack RS, et al. Plant J, 1998 Jun. PMID 9681033
    3. Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins. Halbach T, et al. Nucleic Acids Res, 2000 Sep 15. PMID 10982874, Free PMC Article
    4. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001203938.2
    NM_119140.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    pathogenesis related homeodomain protein A
    NP_001190867.1
    • pathogenesis related homeodomain protein A (PRHA); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Homeodomain-like (InterPro:IPR009057), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain (TAIR:AT3G19510.1).
    NP_194723.1
    • pathogenesis related homeodomain protein A (PRHA); CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain (TAIR:AT3G19510.1); Has 20197 Blast hits to 13808 proteins in 1056 species: Archae - 100; Bacteria - 2032; Metazoa - 7887; Fungi - 1709; Plants - 882; Viruses - 177; Other Eukaryotes - 7410 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14648138..14653489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203938.2 → NP_001190867.1  pathogenesis related homeodomain protein A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V6K6, F4JPG3
      Conserved Domains (3) summary
      cd00086
      Location:454 → 506
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cd15504
      Location:192 → 244
      PHD_PRHA_like; PHD finger found in Arabidopsis thaliana pathogenesis-related homeodomain protein (PRHA) and similar proteins
      pfam14961
      Location:593 → 692
      BROMI; Broad-minded protein

    2. NM_119140.2 → NP_194723.1  pathogenesis related homeodomain protein A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48785
      UniProtKB/TrEMBL
      A0A178V6K6, A0A7G2F6S4
      Conserved Domains (3) summary
      cd00086
      Location:454 → 506
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      TIGR00600
      Location:386 → 727
      rad2; DNA excision repair protein (rad2)
      cd15504
      Location:192 → 244
      PHD_PRHA_like; PHD finger found in Arabidopsis thaliana pathogenesis-related homeodomain protein (PRHA) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48785.1

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