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    alpha/beta-Hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828516, updated on 18-Sep-2024

    Summary

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    Official Full Name
    alpha/beta-Hydrolases superfamily protein
    Primary source
    TAIR:AT4G24160
    Locus tag
    AT4G24160
    See related
    Araport:AT4G24160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T19F6.150; T19F6_150
    Summary
    Encodes a soluble lysophosphatidic acid acyltransferase with additional triacylglycerol lipase and phosphatidylcholine hydrolyzing enzymatic activities. Plays a pivotal role in maintaining the lipid homeostasis by regulating both phospholipid and neutral lipid levels.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (12539656..12542489)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene growth-regulating factor 8 Neighboring gene ATP binding microtubule motor family protein Neighboring gene kinesin-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CGI-58, a key regulator of lipid homeostasis and signaling in plants, also regulates polyamine metabolism. Park S, et al. Plant Signal Behav, 2014. PMID 24492485, Free PMC Article
    2. Disruption of the Arabidopsis CGI-58 homologue produces Chanarin-Dorfman-like lipid droplet accumulation in plants. James CN, et al. Proc Natl Acad Sci U S A, 2010 Oct 12. PMID 20876112, Free PMC Article
    3. The α/β hydrolase CGI-58 and peroxisomal transport protein PXA1 coregulate lipid homeostasis and signaling in Arabidopsis. Park S, et al. Plant Cell, 2013 May. PMID 23667126, Free PMC Article
    4. At4g24160, a soluble acyl-coenzyme A-dependent lysophosphatidic acid acyltransferase. Ghosh AK, et al. Plant Physiol, 2009 Oct. PMID 19700561, Free PMC Article
    5. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CGI-58 and PXA1 contribute to the regulation of polyamine metabolism at the transcriptional level.[CGI-58]
      Title: CGI-58, a key regulator of lipid homeostasis and signaling in plants, also regulates polyamine metabolism.
    2. Data indicate that CGI-58 (At4g24160) interacts with PXA1 into peroxisomes for their subsequent metabolism by beta-oxidation, including fatty acids and lipophilic hormone precursors of the jasmonate and auxin biosynthetic pathways.
      Title: The α/β hydrolase CGI-58 and peroxisomal transport protein PXA1 coregulate lipid homeostasis and signaling in Arabidopsis.
    3. Disruption of the Arabidopsis CGI-58 homologue produces Chanarin-Dorfman-like lipid droplet accumulation in plants.
      Title: Disruption of the Arabidopsis CGI-58 homologue produces Chanarin-Dorfman-like lipid droplet accumulation in plants.
    4. These data establish At4g24160, a protein with a previously unknown function, as an enzyme that might play a pivotal role in maintaining the lipid homeostasis in plants by regulating both phospholipid and neutral lipid levels.
      Title: At4g24160, a soluble acyl-coenzyme A-dependent lysophosphatidic acid acyltransferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_118548.3
    NM_202876.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophosphatidic acid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within fatty acid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    alpha/beta-Hydrolases superfamily protein
    NP_194147.2
    • alpha/beta-Hydrolases superfamily protein; CONTAINS InterPro DOMAIN/s: Alpha/beta hydrolase fold-1 (InterPro:IPR000073); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT1G64670.1); Has 13697 Blast hits to 13658 proteins in 1951 species: Archae - 114; Bacteria - 10198; Metazoa - 427; Fungi - 417; Plants - 428; Viruses - 0; Other Eukaryotes - 2113 (source: NCBI BLink).
    NP_974605.1
    • alpha/beta-Hydrolases superfamily protein; CONTAINS InterPro DOMAIN/s: Alpha/beta hydrolase fold-1 (InterPro:IPR000073); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT1G64670.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12539656..12542489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118548.3 → NP_194147.2  alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194147.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22975, Q9SU43
      UniProtKB/TrEMBL
      A0A178UYX3, A0A5S9XVZ9, A0A654FS96
      Conserved Domains (1) summary
      PLN02894
      Location:16 → 418
      PLN02894; hydrolase, alpha/beta fold family protein

    2. NM_202876.2 → NP_974605.1  alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JQ50
      Conserved Domains (1) summary
      PLN02894
      Location:16 → 340
      PLN02894; hydrolase, alpha/beta fold family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22975.1

    Gene LinkOut

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