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    LDOX leucoanthocyanidin dioxygenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828387, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LDOX
    Official Full Name
    leucoanthocyanidin dioxygenase
    Primary source
    TAIR:AT4G22880
    Locus tag
    AT4G22880
    See related
    Araport:AT4G22880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANS; ANTHOCYANIDIN SYNTHASE; F7H19.60; F7H19_60; leucoanthocyanidin dioxygenase; LEUCOANTHOCYANIDIN DIOXYGENASE; TANNIN DEFICIENT SEED 4; TDS4; TT18
    Summary
    encodes leucoanthocyanidin dioxygenase, which is involved in proanthocyanin biosynthesis. Mutant analysis suggests that this gene is also involved in vacuole formation.
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    Genomic context

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    See LDOX in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (12004726..12006209, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Cell cycle regulated microtubule associated protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene PGR5-LIKE A Neighboring gene transmembrane protein, putative (DUF1191)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolomic and genetic analyses of flavonol synthesis in Arabidopsis thaliana support the in vivo involvement of leucoanthocyanidin dioxygenase. Stracke R, et al. Planta, 2009 Jan. PMID 18998159
    2. Mechanistic study on the oxidation of anthocyanidin synthase by quantum mechanical calculation. Nakajima JI, et al. J Biol Chem, 2006 Jul 28. PMID 16702218
    3. The Arabidopsis TDS4 gene encodes leucoanthocyanidin dioxygenase (LDOX) and is essential for proanthocyanidin synthesis and vacuole development. Abrahams S, et al. Plant J, 2003 Sep. PMID 12940955
    4. Post-translational and transcriptional regulation of phenylpropanoid biosynthesis pathway by Kelch repeat F-box protein SAGL1. Yu SI, et al. Plant Mol Biol, 2019 Jan. PMID 30542810
    5. Characterization of flavonol synthase and leucoanthocyanidin dioxygenase genes in Arabidopsis. Further evidence for differential regulation of "early" and "late" genes. Pelletier MK, et al. Plant Physiol, 1997 Apr. PMID 9112784, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
      Title: Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
    2. The results suggest that SAGL1 regulates phenylpropanoid biosynthesis post-translationally at Phenylalanine ammonia-lyase (PAL) and transcriptionally at ANTHOCYANIDIN SYNTHASE (ANS).
      Title: Post-translational and transcriptional regulation of phenylpropanoid biosynthesis pathway by Kelch repeat F-box protein SAGL1.
    3. The remaining flavonol glycosides found in the fls1-2 mutant are synthesized in planta by the FLS-like side activity of the LDOX enzyme.
      Title: Metabolomic and genetic analyses of flavonol synthesis in Arabidopsis thaliana support the in vivo involvement of leucoanthocyanidin dioxygenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036623.1
    NM_001341563.1
    NM_118417.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables leucocyanidin oxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anthocyanin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within proanthocyanidin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    leucoanthocyanidin dioxygenase
    NP_001320035.1
    • leucoanthocyanidin dioxygenase (LDOX); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: flavonol synthase 1 (TAIR:AT5G08640.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_194019.1
    • leucoanthocyanidin dioxygenase (LDOX); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: flavonol synthase 1 (TAIR:AT5G08640.2); Has 8356 Blast hits to 8311 proteins in 977 species: Archae - 0; Bacteria - 1058; Metazoa - 85; Fungi - 889; Plants - 4934; Viruses - 0; Other Eukaryotes - 1390 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12004726..12006209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341563.1 → NP_001320035.1  leucoanthocyanidin dioxygenase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96323
      UniProtKB/TrEMBL
      A0A178V1T6, A0A7G2F072, Q0WWD6, Q7Y0R2
      Conserved Domains (1) summary
      PLN03178
      Location:1 → 356
      PLN03178; leucoanthocyanidin dioxygenase; Provisional

    2. NM_118417.2 → NP_194019.1  leucoanthocyanidin dioxygenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194019.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96323
      UniProtKB/TrEMBL
      A0A178V1T6, A0A7G2F072, Q0WWD6, Q7Y0R2
      Conserved Domains (1) summary
      PLN03178
      Location:1 → 356
      PLN03178; leucoanthocyanidin dioxygenase; Provisional

    3. NM_001036623.1 → NP_001031700.1  leucoanthocyanidin dioxygenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031700.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96323
      UniProtKB/TrEMBL
      A0A178V1T6, A0A7G2F072, Q0WWD6, Q7Y0R2
      Conserved Domains (1) summary
      PLN03178
      Location:1 → 356
      PLN03178; leucoanthocyanidin dioxygenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96323.1

    Gene LinkOut

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