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    ZAC [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827864, updated on 22-Aug-2024

    Summary

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    Official Symbol
    ZAC
    Primary source
    Araport:AT4G21160
    Locus tag
    AT4G21160
    See related
    TAIR:AT4G21160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGD12; ARF-GAP domain 12
    Summary
    ADP-ribosylation factor GTPase-activating protein containing zinc finger and C2 domains and a novel PI-3-P-binding protein region. Binds PI-3-P. Highest expression levels in flowering tissue, rosettes and roots. A member of ARF GAP domain (AGD), A thaliana has 15 members, grouped into four classes.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (11284076..11286767)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene copper ion-binding protein Neighboring gene ribophorin II (RPN2) family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene DnaJ / Sec63 Brl domains-containing protein Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Promiscuous and specific phospholipid binding by domains in ZAC, a membrane-associated Arabidopsis protein with an ARF GAP zinc finger and a C2 domain. Jensen RB, et al. Plant Mol Biol, 2000 Dec. PMID 11202441
    2. EHB1 and AGD12, two calcium-dependent proteins affect gravitropism antagonistically in Arabidopsis thaliana. Dümmer M, et al. J Plant Physiol, 2016 Nov 1. PMID 27728837
    3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In contrast to agd12 mutants, ehb1 loss-of function seedlings displayed enhanced gravitropic bending.
      Title: EHB1 and AGD12, two calcium-dependent proteins affect gravitropism antagonistically in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118235.4
    NM_179085.3
    NM_202852.2
    NM_202853.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calcium-dependent ARF-type GTPase activating protein family
    NP_567620.1
    • ZAC; FUNCTIONS IN: phospholipid binding, ARF GTPase activator activity; INVOLVED IN: intracellular protein transport; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 13 (TAIR:AT4G05330.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849416.1
    • ZAC; FUNCTIONS IN: phospholipid binding, ARF GTPase activator activity; INVOLVED IN: intracellular protein transport; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 13 (TAIR:AT4G05330.1); Has 8253 Blast hits to 7394 proteins in 304 species: Archae - 0; Bacteria - 3; Metazoa - 4692; Fungi - 1290; Plants - 1388; Viruses - 0; Other Eukaryotes - 880 (source: NCBI BLink).
    NP_974581.1
    • ZAC; FUNCTIONS IN: phospholipid binding, ARF GTPase activator activity; INVOLVED IN: intracellular protein transport; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 13 (TAIR:AT4G05330.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974582.1
    • ZAC; FUNCTIONS IN: phospholipid binding, ARF GTPase activator activity; INVOLVED IN: intracellular protein transport; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 13 (TAIR:AT4G05330.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11284076..11286767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118235.4 → NP_567620.1  Calcium-dependent ARF-type GTPase activating protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49557, Q0WNN1, Q8L9H2, Q9FVJ3
      UniProtKB/TrEMBL
      A0A178UUS8, A0A5S9XUC9
      Conserved Domains (2) summary
      cd04038
      Location:180 → 324
      C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)
      cd08204
      Location:18 → 124
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

    2. NM_202852.2 → NP_974581.1  Calcium-dependent ARF-type GTPase activating protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974581.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49557, Q0WNN1, Q8L9H2, Q9FVJ3
      UniProtKB/TrEMBL
      A0A178UUS8, A0A5S9XUC9
      Conserved Domains (2) summary
      cd04038
      Location:180 → 324
      C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)
      cd08204
      Location:18 → 124
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

    3. NM_202853.3 → NP_974582.1  Calcium-dependent ARF-type GTPase activating protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49557, Q0WNN1, Q8L9H2, Q9FVJ3
      UniProtKB/TrEMBL
      A0A178UUS8, A0A5S9XUC9
      Conserved Domains (2) summary
      cd04038
      Location:180 → 324
      C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)
      cd08204
      Location:18 → 124
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

    4. NM_179085.3 → NP_849416.1  Calcium-dependent ARF-type GTPase activating protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849416.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49557, Q0WNN1, Q8L9H2, Q9FVJ3
      UniProtKB/TrEMBL
      A0A178UUS8, A0A5S9XUC9
      Conserved Domains (2) summary
      cd04038
      Location:180 → 324
      C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)
      cd08204
      Location:18 → 124
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FVJ3.1

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