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    NIG NSP (nuclear shuttle protein)-interacting GTPase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826966, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NIG
    Official Full Name
    NSP (nuclear shuttle protein)-interacting GTPase
    Primary source
    TAIR:AT4G13350
    Locus tag
    AT4G13350
    See related
    Araport:AT4G13350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    NSP (nuclear shuttle protein)-interacting GTPase; T9E8.90; T9E8_90
    Summary
    Encodes a GTPase that interacts with nuclear shuttle proteins (NSPs) from a number of different plant viruses. The gene is widely expressed and NIG transcript levels do not rise in response to viral infection. This cytoplasmic protein does not directly interact with a viral movement protein (MP), but, it does promote the movement of NSP from the nucleus to the cytoplasm. Overexpression of NIG in Arabidopsis plants renders them more sensitive to geminivirus infection.
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    Genomic context

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    See NIG in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Sequence:
    Chromosome: 4; NC_003075.7 (7769716..7773827, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene uncharacterized protein Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene Serinc-domain containing serine and sphingolipid biosynthesis protein Neighboring gene ATP-dependent caseinolytic (Clp) protease/crotonase family protein Neighboring gene serine/arginine repetitive matrix protein, putative (DUF936) Neighboring gene Heavy metal transport/detoxification superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel nucleocytoplasmic traffic GTPase identified as a functional target of the bipartite geminivirus nuclear shuttle protein. Carvalho CM, et al. Plant J, 2008 Sep. PMID 18489709
    2. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NIG protein is a GTPase that interacts with geminivirus nuclear shuttle protein. NIG increases the nuclear export rates of viral NSP which contributes to geminivirus infection. [NIG]
      Title: A novel nucleocytoplasmic traffic GTPase identified as a functional target of the bipartite geminivirus nuclear shuttle protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_117409.5
    NM_179209.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NSP (nuclear shuttle protein)-interacting GTPase
    NP_193071.2
    • NSP (nuclear shuttle protein)-interacting GTPase (NIG); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: nucleocytoplasmic transport, response to virus; LOCATED IN: cytosol, cytoplasm; EXPRESSED IN: flower, root, cultured cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164); BEST Arabidopsis thaliana protein match is: ArfGap/RecO-like zinc finger domain-containing protein (TAIR:AT4G32630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849540.1
    • NSP (nuclear shuttle protein)-interacting GTPase (NIG); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: nucleocytoplasmic transport, response to virus; LOCATED IN: cytosol, cytoplasm; EXPRESSED IN: flower, root, cultured cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164); BEST Arabidopsis thaliana protein match is: ArfGap/RecO-like zinc finger domain-containing protein (TAIR:AT4G32630.1); Has 7463 Blast hits to 6530 proteins in 396 species: Archae - 2; Bacteria - 285; Metazoa - 3343; Fungi - 1586; Plants - 848; Viruses - 60; Other Eukaryotes - 1339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7769716..7773827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117409.5 → NP_193071.2  NSP (nuclear shuttle protein)-interacting GTPase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193071.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V2M7, A0A7G2F253, Q8W4K6
      Conserved Domains (1) summary
      PLN03131
      Location:3 → 515
      PLN03131; hypothetical protein; Provisional

    2. NM_179209.2 → NP_849540.1  NSP (nuclear shuttle protein)-interacting GTPase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V2M7, A0A7G2F253, Q8W4K6
      Conserved Domains (1) summary
      PLN03131
      Location:3 → 515
      PLN03131; hypothetical protein; Provisional
    Nucleotide Protein
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