RANGAP1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RANGAP1
Primary source: Araport:AT3G63130
Locus tag: AT3G63130
See related: TAIR:AT3G63130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRANGAP1; RAN GTPase activating protein 1; RAN GTPASE-ACTIVATING PROTEIN 1
Summary: Encodes a RAN GTPase activating protein involved in nuclear import, cell plate formation and mitotic spindle formation.
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Genomic context

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See RANGAP1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (23324479..23326973)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtGAP1 Promotes the Resistance to Pseudomonas syringae pv. tomato DC3000 by Regulating Cell-Wall Thickness and Stomatal Aperture in Arabidopsis.
Title: AtGAP1 Promotes the Resistance to Pseudomonas syringae pv. tomato DC3000 by Regulating Cell-Wall Thickness and Stomatal Aperture in Arabidopsis.
The data show that plant development is differentially affected by RanGAP mutant allele combinations of increasing severity and requires the GAP activity of RanGAP, while the subcellular positioning of RanGAP is dispensable.
Title: GAP Activity, but Not Subcellular Targeting, Is Required for Arabidopsis RanGAP Cellular and Developmental Functions.
These results show that the two RanGAPs are redundant and indispensable for female gametophyte development in Arabidopsis but dispensable for pollen development.
Title: RanGAP is required for post-meiotic mitosis in female gametophyte development in Arabidopsis thaliana.
These data suggest that both HSC70-1 and the WPP-domain proteins play a role in facilitating WIT1 nuclear envelope targeting; this may be the first described in planta activity for the WPP-domain proteins.
Title: WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1.
propose that Arabidopsis RanGAP, a continuous positive protein marker of the plant division plane, has a role in spatial signaling during plant cell division
Title: RanGAP1 is a continuous marker of the Arabidopsis cell division plane.
Data suggest that an unanticipated complexity of RanGAP nuclear envelope targeting and at least one member of each NE-associated coiled-coil and transmembrane domains protein family is required for RanGAP targeting in root tip cells.
Title: Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP.
In a wip1-1/wip2-1/wip3-1 triple mutant, RanGAP1 is dislocated from the nuclear envelope in undifferentiated root-tip cells, whereas nuclear envelope targeting in differentiated root cells and targeting to the cell plate remain intact.
Title: Anchorage of plant RanGAP to the nuclear envelope involves novel nuclear-pore-associated proteins.
AtRanGAP1 has a mitotic trafficking pattern uniquely different from that of vertebrate RanGAP.
Title: Plant-specific mitotic targeting of RanGAP requires a functional WPP domain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203237.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokinesis by cell plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into nucleus	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell division site	IDA Inferred from Direct Assay more info	PubMed
located_in cell plate	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: RAN GTPase activating protein 1

NP_001190166.1

RAN GTPase activating protein 1 (RANGAP1); FUNCTIONS IN: RAN GTPase activator activity; INVOLVED IN: M phase specific microtubule process, protein import into nucleus; LOCATED IN: nuclear envelope, cell plate; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; BEST Arabidopsis thaliana protein match is: RAN GTPase activating protein 2 (TAIR:AT5G19320.1).

NP_191872.1

RAN GTPase activating protein 1 (RANGAP1); FUNCTIONS IN: RAN GTPase activator activity; INVOLVED IN: M phase specific microtubule process, protein import into nucleus, cytokinesis; LOCATED IN: nuclear envelope, plasma membrane, chloroplast, cell division site, cell plate; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; BEST Arabidopsis thaliana protein match is: RAN GTPase activating protein 2 (TAIR:AT5G19320.1); Has 11260 Blast hits to 5482 proteins in 299 species: Archae - 0; Bacteria - 610; Metazoa - 5101; Fungi - 238; Plants - 692; Viruses - 0; Other Eukaryotes - 4619 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

23324479..23326973

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116178.3 → NP_191872.1 RAN GTPase activating protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191872.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LE82

UniProtKB/TrEMBL

A0A178VJ78, A0A5S9XQ13, A0A654FKB2

Conserved Domains (3) summary

sd00033
Location:211 → 234

LRR_RI; leucine-rich repeat [structural motif]

pfam13943
Location:14 → 110

WPP; WPP domain

cl39015
Location:133 → 446

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001203237.1 → NP_001190166.1 RAN GTPase activating protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190166.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LE82

UniProtKB/TrEMBL

A0A178VJ78, A0A5S9XQ13, A0A654FKB2

Conserved Domains (3) summary

sd00033
Location:211 → 234

LRR_RI; leucine-rich repeat [structural motif]

pfam13943
Location:14 → 110

WPP; WPP domain

cl39015
Location:133 → 446

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...