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    TTN8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824632, updated on 22-Aug-2024

    Summary

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    Official Symbol
    TTN8
    Primary source
    Araport:AT3G54670
    Locus tag
    AT3G54670
    See related
    TAIR:AT3G54670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSMC1; SMC1; STRUCTURAL MAINTENANCE OF CHROMOSOMES 1; TITAN8
    Summary
    Encodes a member of the Arabidopsis cohesin complex that is essential for viability and sister chromatid alignment.
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    Genomic context

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    See TTN8 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Sequence:
    Chromosome: 3; NC_003074.8 (20235506..20244046)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNI-like superfamily protein Neighboring gene glutathione reductase Neighboring gene proteophosphoglycan-like protein Neighboring gene Sugar isomerase (SIS) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Condensin and cohesin knockouts in Arabidopsis exhibit a titan seed phenotype. Liu Cm CM, et al. Plant J, 2002 Feb. PMID 11846874
    2. Cohesin gene defects may impair sister chromatid alignment and genome stability in Arabidopsis thaliana. Schubert V, et al. Chromosoma, 2009 Oct. PMID 19533160
    3. Identification and molecular properties of SUMO-binding proteins in Arabidopsis. Park HC, et al. Mol Cells, 2011 Aug. PMID 21607647, Free PMC Article
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339686.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cohesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Structural maintenance of chromosomes (SMC) family protein
    NP_001319748.1
    • TITAN8 (TTN8); FUNCTIONS IN: transporter activity, ATP binding; INVOLVED IN: sister chromatid cohesion, chromosome segregation; LOCATED IN: cohesin complex, nucleus, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: SMCs flexible hinge (InterPro:IPR010935), RecF/RecN/SMC protein, N-terminal (InterPro:IPR003395); BEST Arabidopsis thaliana protein match is: structural maintenance of chromosome 3 (TAIR:AT5G48600.1); Has 200429 Blast hits to 91047 proteins in 3650 species: Archae - 2506; Bacteria - 36447; Metazoa - 81443; Fungi - 15311; Plants - 9097; Viruses - 946; Other Eukaryotes - 54679 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20235506..20244046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339686.1 → NP_001319748.1  Structural maintenance of chromosomes (SMC) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JE01, F4JE02, Q0WSY5, Q6Q1P4, Q9M1T3
      UniProtKB/TrEMBL
      A0A5S9XKT5, A0A654FHX4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q1P4.2

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