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    FK Ergosterol biosynthesis ERG4/ERG24 family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824460, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FK
    Official Full Name
    Ergosterol biosynthesis ERG4/ERG24 family
    Primary source
    TAIR:AT3G52940
    Locus tag
    AT3G52940
    See related
    Araport:AT3G52940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ELL1; EXTRA-LONG-LIFESPAN 1; FACKEL; HYD2
    Summary
    Encodes a sterol C-14 reductase required for cell division and expansion and is involved in proper organization of the embryo.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (19630077..19633328, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene transcriptional activator (DUF662) Neighboring gene Aldolase superfamily protein Neighboring gene Putative membrane lipoprotein Neighboring gene CBS / octicosapeptide/Phox/Bemp1 (PB1) domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sterols are required for cell-fate commitment and maintenance of the stomatal lineage in Arabidopsis. Qian P, et al. Plant J, 2013 Jun. PMID 23551583
    2. A critical role of sterols in embryonic patterning and meristem programming revealed by the fackel mutants of Arabidopsis thaliana. Jang JC, et al. Genes Dev, 2000 Jun 15. PMID 10859167, Free PMC Article
    3. FACKEL is a sterol C-14 reductase required for organized cell division and expansion in Arabidopsis embryogenesis. Schrick K, et al. Genes Dev, 2000 Jun 15. PMID 10859166, Free PMC Article
    4. Fackel interacts with gibberellic acid signaling and vernalization to mediate flowering in Arabidopsis. Huang B, et al. Planta, 2017 May. PMID 28108812
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_115154.3
    NM_202691.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables delta14-sterol reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables delta14-sterol reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Ergosterol biosynthesis ERG4/ERG24 family
    NP_566975.1
    • FACKEL (FK); FUNCTIONS IN: delta14-sterol reductase activity; INVOLVED IN: sterol biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sterol reductase, conserved site (InterPro:IPR018083), Ergosterol biosynthesis ERG4/ERG24 (InterPro:IPR001171); BEST Arabidopsis thaliana protein match is: Ergosterol biosynthesis ERG4/ERG24 family (TAIR:AT1G50430.2); Has 1188 Blast hits to 1183 proteins in 251 species: Archae - 2; Bacteria - 118; Metazoa - 269; Fungi - 413; Plants - 205; Viruses - 3; Other Eukaryotes - 178 (source: NCBI BLink).
    NP_974420.1
    • FACKEL (FK); FUNCTIONS IN: delta14-sterol reductase activity; INVOLVED IN: sterol biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sterol reductase, conserved site (InterPro:IPR018083), Ergosterol biosynthesis ERG4/ERG24 (InterPro:IPR001171); BEST Arabidopsis thaliana protein match is: Ergosterol biosynthesis ERG4/ERG24 family (TAIR:AT1G50430.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19630077..19633328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115154.3 → NP_566975.1  Ergosterol biosynthesis ERG4/ERG24 family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LD62, Q9LDR4
      UniProtKB/TrEMBL
      A0A654FGX0, A0A7G2EWX1, Q0WUH0
      Conserved Domains (1) summary
      cl21511
      Location:4 → 369
      PEMT; Phospholipid methyltransferase

    2. NM_202691.1 → NP_974420.1  Ergosterol biosynthesis ERG4/ERG24 family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J859
      Conserved Domains (1) summary
      cl21511
      Location:4 → 229
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LDR4.2

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