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    VTC4 Inositol monophosphatase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821206, updated on 7-Sep-2023

    Summary

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    Gene symbol
    VTC4
    Gene description
    Inositol monophosphatase family protein
    Primary source
    Araport:AT3G02870
    Locus tag
    AT3G02870
    See related
    TAIR:AT3G02870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F13E7.19; F13E7_19
    Summary
    Encodes a L-galactose-1-phosphate phosphatase, involved in ascorbate biosynthesis.
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    Genomic context

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    See VTC4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (627512..629925, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene STELAR K+ outward rectifier Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene Peptidase M20/M25/M40 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme. Conklin PL, et al. J Biol Chem, 2006 Jun 9. PMID 16595667
    2. A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis. Laing WA, et al. Proc Natl Acad Sci U S A, 2004 Nov 30. PMID 15550539, Free PMC Article
    3. VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants. Torabinejad J, et al. Plant Physiol, 2009 Jun. PMID 19339506, Free PMC Article
    4. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VTC4 is a bifunctional enzyme that impacts both myoinositol and ascorbate synthesis pathways.
      Title: VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035549.1
    NM_001125086.1
    NM_111155.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-galactose-1-phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-galactose-1-phosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inositol monophosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol monophosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Inositol monophosphatase family protein
    NP_001030626.1
    • VTC4; FUNCTIONS IN: 3'(2'),5'-bisphosphate nucleotidase activity, L-galactose-1-phosphate phosphatase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity; INVOLVED IN: sulfur metabolic process, L-ascorbic acid biosynthetic process, response to karrikin, response to cold, inositol biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol monophosphatase, conserved site (InterPro:IPR020550), Inositol monophosphatase (InterPro:IPR000760), Inositol monophosphatase, metal-binding site (InterPro:IPR020583); BEST Arabidopsis thaliana protein match is: myo-inositol monophosphatase like 1 (TAIR:AT1G31190.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001118558.1
    • VTC4; FUNCTIONS IN: 3'(2'),5'-bisphosphate nucleotidase activity, L-galactose-1-phosphate phosphatase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity; INVOLVED IN: sulfur metabolic process, L-ascorbic acid biosynthetic process, response to karrikin, response to cold, inositol biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol monophosphatase, conserved site (InterPro:IPR020550), Inositol monophosphatase (InterPro:IPR000760), Inositol monophosphatase, Lithium-sensitive (InterPro:IPR020552), Inositol monophosphatase, metal-binding site (InterPro:IPR020583); BEST Arabidopsis thaliana protein match is: myo-inositol monophosphatase like 1 (TAIR:AT1G31190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_186936.1
    • VTC4; FUNCTIONS IN: 3'(2'),5'-bisphosphate nucleotidase activity, L-galactose-1-phosphate phosphatase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity; INVOLVED IN: sulfur metabolic process, L-ascorbic acid biosynthetic process, response to karrikin, response to cold, inositol biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol monophosphatase, conserved site (InterPro:IPR020550), Inositol monophosphatase (InterPro:IPR000760), Inositol monophosphatase, metal-binding site (InterPro:IPR020583), Inositol monophosphatase, Lithium-sensitive (InterPro:IPR020552); BEST Arabidopsis thaliana protein match is: myo-inositol monophosphatase like 1 (TAIR:AT1G31190.1); Has 16249 Blast hits to 16237 proteins in 2366 species: Archae - 250; Bacteria - 8645; Metazoa - 648; Fungi - 322; Plants - 290; Viruses - 0; Other Eukaryotes - 6094 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      627512..629925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111155.3 → NP_186936.1  Inositol monophosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LE95, Q9M8S8
      UniProtKB/TrEMBL
      A0A178V8V9, A0A5S9X8K5, A0A7G2EFC4
      Conserved Domains (1) summary
      PLN02553
      Location:1 → 269
      PLN02553; inositol-phosphate phosphatase

    2. NM_001125086.1 → NP_001118558.1  Inositol monophosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118558.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EFC4, B3H749
      Conserved Domains (1) summary
      PLN02553
      Location:3 → 266
      PLN02553; inositol-phosphate phosphatase

    3. NM_001035549.1 → NP_001030626.1  Inositol monophosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EFC4, F4IYH1
      Conserved Domains (1) summary
      PLN02553
      Location:1 → 267
      PLN02553; inositol-phosphate phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8S8.1

    Gene LinkOut

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