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    LSF2 dual specificity protein phosphatase (DsPTP1) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820265, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LSF2
    Official Full Name
    dual specificity protein phosphatase (DsPTP1) family protein
    Primary source
    TAIR:AT3G10940
    Locus tag
    AT3G10940
    See related
    Araport:AT3G10940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LIKE SEX4 2
    Summary
    Encodes a protein with a predicted dual-specificity phosphatase domain, similar to the glucan phosphorylases SEX4 and LSF1, however, it lacks the carbohydrate binding domain present in those proteins. Has phosphoglucan phosphatase activity. It binds to starch and specifically hydrolyzes phosphate from the C3-position.
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    Genomic context

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    See LSF2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (3422034..3423455, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene manganese superoxide dismutase 1 Neighboring gene uncharacterized protein Neighboring gene Zinc-binding ribosomal protein family protein Neighboring gene AZA-guanine resistant1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The LIKE SEX FOUR2 regulates root development by modulating reactive oxygen species homeostasis in Arabidopsis. Zhao P, et al. Sci Rep, 2016 Jun 28. PMID 27349915, Free PMC Article
    2. Structure of the Arabidopsis glucan phosphatase like sex four2 reveals a unique mechanism for starch dephosphorylation. Meekins DA, et al. Plant Cell, 2013 Jun. PMID 23832589, Free PMC Article
    3. The phosphoglucan phosphatase like sex Four2 dephosphorylates starch at the C3-position in Arabidopsis. Santelia D, et al. Plant Cell, 2011 Nov. PMID 22100529, Free PMC Article
    4. Plant α-glucan phosphatases SEX4 and LSF2 display different affinity for amylopectin and amylose. Wilkens C, et al. FEBS Lett, 2016 Jan. PMID 26763114
    5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings indicated the novel function of LSF2 that controls ROS homeostasis to regulate root development.
      Title: The LIKE SEX FOUR2 regulates root development by modulating reactive oxygen species homeostasis in Arabidopsis.
    2. Data suggest LSF2 has 50-fold lower affinity for amylopectin compared to SEX4, indicating LSF2 more easily dissociates from starch granule; SEX4 prefers amylopectin; LSF2 has highest affinity toward amylose with 8-fold higher affinity compared to SEX4.
      Title: Plant α-glucan phosphatases SEX4 and LSF2 display different affinity for amylopectin and amylose.
    3. Data indicate two additional glucan binding sites were identified within the core glucan phosphatase like sex four2 (LSF2) phosphatase domain.
      Title: Structure of the Arabidopsis glucan phosphatase like sex four2 reveals a unique mechanism for starch dephosphorylation.
    4. LSF2 is involved in starch metabolism in Arabidopsis chloroplasts
      Title: The phosphoglucan phosphatase like sex Four2 dephosphorylates starch at the C3-position in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_111931.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbohydrate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables starch binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sugar-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in starch catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in starch catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase (DsPTP1) family protein
    NP_566383.1
    • dual specificity protein phosphatase (DsPTP1) family protein; FUNCTIONS IN: phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation, dephosphorylation; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase (DsPTP1) family protein (TAIR:AT3G52180.2); Has 897 Blast hits to 897 proteins in 122 species: Archae - 6; Bacteria - 12; Metazoa - 607; Fungi - 18; Plants - 142; Viruses - 11; Other Eukaryotes - 101 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3422034..3423455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111931.3 → NP_566383.1  dual specificity protein phosphatase (DsPTP1) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBS6, Q9SRK5
      UniProtKB/TrEMBL
      A0A178V8E2, A0A654FGH8
      Conserved Domains (1) summary
      cd14526
      Location:91 → 238
      DSP_laforin-like; dual specificity phosphatase domain of laforin and similar domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SRK5.1

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