IBR3 acyl-CoA dehydrogenase-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: IBR3
Official Full Name: acyl-CoA dehydrogenase-like protein
Primary source: TAIR:AT3G06810
Locus tag: AT3G06810
See related: Araport:AT3G06810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT3G06800; IBA-RESPONSE 3
Summary: Encodes a protein with similarity to acyl-CoA dehydrogenases. Mutations in IBR3 render plants resistant to indole-3-butryic acid, a putative storage form of the biologically active auxin IAA (indole-3-acetic acid). IBR3 is hypothesized to carry out the second step in a beta-oxidation-like process of IBA metabolism in Arabidopsis. Though its subcellular location has not been determined, IBR3 has a peroxisomal targeting sequence and two other putative IBA metabolic enzymes (IBR1 and IBR10) can be found in this organelle. No specific enzymatic activity has been documented for IBR3, but double mutant analyses with CHY1 argue against a role for IBR3 in general fatty acid beta-oxidation.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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Results suggest a novel role for IBR3 in A. thaliana defence response against bacterial pathogens. [IBA-RESPONSE 3] [IBR3]
Title: Arabidopsis thaliana transgenics overexpressing IBR3 show enhanced susceptibility to the bacterium Pseudomonas syringae.
IBR3, IBR10, and IBR1 may act sequentially in peroxisomal IBA beta-oxidation to IAA
Title: Identification and characterization of Arabidopsis indole-3-butyric acid response mutants defective in novel peroxisomal enzymes.
IBR3 encodes a putative acyl-CoA dehydrogenase that has a role in the oxidation of indole-3-butyric acid to indole-3-acetic acid.
Title: IBR3, a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric acid response.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_111561.5

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within root hair elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

NP_187337.2

IBA-RESPONSE 3 (IBR3); FUNCTIONS IN: acyl-CoA dehydrogenase activity, oxidoreductase activity; INVOLVED IN: root hair elongation; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA oxidase/dehydrogenase, type 1 (InterPro:IPR006090), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA dehydrogenase/oxidase, N-terminal (InterPro:IPR013786), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075), Protein kinase-like domain (InterPro:IPR011009), Acyl-CoA dehydrogenase, N-terminal (InterPro:IPR006092), Aminoglycoside phosphotransferase (InterPro:IPR002575); BEST Arabidopsis thaliana protein match is: isovaleryl-CoA-dehydrogenase (TAIR:AT3G45300.1); Has 35245 Blast hits to 35197 proteins in 1774 species: Archae - 552; Bacteria - 22616; Metazoa - 1388; Fungi - 871; Plants - 174; Viruses - 0; Other Eukaryotes - 9644 (source: NCBI BLink).