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    HST ARM repeat superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819666, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HST
    Official Full Name
    ARM repeat superfamily protein
    Primary source
    TAIR:AT3G05040
    Locus tag
    AT3G05040
    See related
    Araport:AT3G05040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HASTY; HASTY 1; HST1; T9J14.1; T9J14_1
    Summary
    Encodes member of importin/exportin family. Involved in timing of shoot maturation. Involved in miRNA transport. Mutants flower early and have small, curled leaves and reduced abundance of certain miRNA species.
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    Genomic context

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    See HST in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    22
    Sequence:
    Chromosome: 3; NC_003074.8 (1401171..1408302, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene exportin-4 protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene ncRNA Neighboring gene NOP56-like pre RNA processing ribonucleoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HASTY, the Arabidopsis EXPORTIN5 ortholog, regulates cell-to-cell and vascular microRNA movement. Brioudes F, et al. EMBO J, 2021 Aug 2. PMID 34152631, Free PMC Article
    2. HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing. Cambiagno DA, et al. Mol Plant, 2021 Mar 1. PMID 33385584
    3. Nuclear processing and export of microRNAs in Arabidopsis. Park MY, et al. Proc Natl Acad Sci U S A, 2005 Mar 8. PMID 15738428, Free PMC Article
    4. HASTY: a gene that regulates the timing of shoot maturation in Arabidopsis thaliana. Telfer A, et al. Development, 1998 May. PMID 9550721
    5. Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis. Sadre R, et al. J Biol Chem, 2010 Jun 11. PMID 20400515, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis.
      Title: HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis.
    2. HASTY, the Arabidopsis EXPORTIN5 ortholog, regulates cell-to-cell and vascular microRNA movement.
      Title: HASTY, the Arabidopsis EXPORTIN5 ortholog, regulates cell-to-cell and vascular microRNA movement.
    3. HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing.
      Title: HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing.
    4. analysis of catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis
      Title: Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337559.1
    NM_111376.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear export signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within polarity specification of adaxial/abaxial axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope NAS
    Non-traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ARM repeat superfamily protein
    NP_187155.2
    • HASTY (HST); CONTAINS InterPro DOMAIN/s: Exportin-1/Importin-beta-like (InterPro:IPR013598), Armadillo-type fold (InterPro:IPR016024); Has 520 Blast hits to 417 proteins in 141 species: Archae - 0; Bacteria - 0; Metazoa - 205; Fungi - 183; Plants - 102; Viruses - 0; Other Eukaryotes - 30 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1401171..1408302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111376.4 → NP_187155.2  ARM repeat superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187155.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WP44, Q84UC4, Q9CAW7
      UniProtKB/TrEMBL
      A0A178VI74, A0A654F5L5
      Conserved Domains (1) summary
      pfam08389
      Location:106 → 266
      Xpo1; Exportin 1-like protein

    2. NM_001337559.1 → NP_001327303.1  ARM repeat superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VI74, A0A1I9LRW7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WP44.1

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