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    LRB1 BTB/POZ/Kelch-associated protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819234, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LRB1
    Official Full Name
    BTB/POZ/Kelch-associated protein
    Primary source
    TAIR:AT2G46260
    Locus tag
    AT2G46260
    See related
    Araport:AT2G46260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    light-response BTB 1; T3F17.9
    Summary
    Involvement in protein ubiquitylation is predicted based on physical interaction with CULLIN 3 proteins.
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    Genomic context

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    See LRB1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (18995645..18998672)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene myosin heavy chain-like protein Neighboring gene ncRNA Neighboring gene G-box binding factor 3 Neighboring gene TGF-beta receptor interacting protein 1 Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The light-response BTB1 and BTB2 proteins assemble nuclear ubiquitin ligases that modify phytochrome B and D signaling in Arabidopsis. Christians MJ, et al. Plant Physiol, 2012 Sep. PMID 22732244, Free PMC Article
    2. MATH/BTB CRL3 receptors target the homeodomain-leucine zipper ATHB6 to modulate abscisic acid signaling. Lechner E, et al. Dev Cell, 2011 Dec 13. PMID 22172674
    3. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRB1 (LIGHT-RESPONSE BTB1) and LRB2 (LIGHT-RESPONSE BTB2) are involved in many developmental processes mediated by phytochrome B and phytochrome D.
      Title: The light-response BTB1 and BTB2 proteins assemble nuclear ubiquitin ligases that modify phytochrome B and D signaling in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_130189.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to red light IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ/Kelch-associated protein
    NP_566069.1
    • BTB/POZ/Kelch-associated protein; CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), BTB/Kelch-associated (InterPro:IPR011705), BTB/POZ fold (InterPro:IPR011333), Kelch related (InterPro:IPR013089), BTB/POZ-like (InterPro:IPR000210); BEST Arabidopsis thaliana protein match is: POZ/BTB containin G-protein 1 (TAIR:AT3G61600.1); Has 3374 Blast hits to 3358 proteins in 97 species: Archae - 0; Bacteria - 0; Metazoa - 3133; Fungi - 0; Plants - 140; Viruses - 10; Other Eukaryotes - 91 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18995645..18998672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130189.3 → NP_566069.1  BTB/POZ/Kelch-associated protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82343, Q56WV2, Q8LG00, Q94AI9
      UniProtKB/TrEMBL
      A0A178VTN1, A0A5S9X7G9
      Conserved Domains (2) summary
      smart00875
      Location:266 → 351
      BACK; BTB And C-terminal Kelch
      cd18186
      Location:144 → 226
      BTB_POZ_ZBTB_KLHL-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82343.2

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