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    FAH1 fatty acid hydroxylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818042, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAH1
    Official Full Name
    fatty acid hydroxylase 1
    Primary source
    TAIR:AT2G34770
    Locus tag
    AT2G34770
    See related
    Araport:AT2G34770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS FATTY ACID HYDROXYLASE 1; ATFAH1; FAH1P; fatty acid hydroxylase 1; T29F13.2; T29F13_2
    Summary
    encodes a fatty acid hydroxylase, required for the AtBI-1-mediated suppression of programmed cell death.
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    Genomic context

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    See FAH1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (14665667..14668250)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene myosin heavy chain-like protein Neighboring gene protein phosphatase 2C family protein Neighboring gene RNA polymerase I specific transcription initiation factor RRN3 protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene maternal effect embryo arrest 22 Neighboring gene ncRNA Neighboring gene FAD-binding Berberine family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis mutants of sphingolipid fatty acid α-hydroxylases accumulate ceramides and salicylates. König S, et al. New Phytol, 2012 Dec. PMID 23025549
    2. Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses. Nagano M, et al. Plant Physiol, 2012 Jul. PMID 22635113, Free PMC Article
    3. Functional association of cell death suppressor, Arabidopsis Bax inhibitor-1, with fatty acid 2-hydroxylation through cytochrome b₅. Nagano M, et al. Plant J, 2009 Apr. PMID 19054355
    4. Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Mitchell AG, et al. J Biol Chem, 1997 Nov 7. PMID 9353282
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAH1 enzyme is capable of forming alpha-hydroxylated ceramides.
      Title: Arabidopsis mutants of sphingolipid fatty acid α-hydroxylases accumulate ceramides and salicylates.
    2. AtFAH1 and AtFAH2 had fatty acid 2-hydroxylase activity, and the interaction with Arabidopsis cytochrome b5 was needed for the sufficient activity.
      Title: Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129030.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fatty acid 2-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid 2-hydroxylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within very long-chain fatty acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acid hydroxylase 1
    NP_181023.1
    • fatty acid hydroxylase 1 (FAH1); FUNCTIONS IN: fatty acid alpha-hydroxylase activity, catalytic activity; INVOLVED IN: very long-chain fatty acid metabolic process, negative regulation of programmed cell death; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: fatty acid hydroxylase 2 (TAIR:AT4G20870.1); Has 784 Blast hits to 784 proteins in 354 species: Archae - 0; Bacteria - 388; Metazoa - 105; Fungi - 140; Plants - 78; Viruses - 0; Other Eukaryotes - 73 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14665667..14668250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129030.2 → NP_181023.1  fatty acid hydroxylase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48916
      UniProtKB/TrEMBL
      A0A178W0P1, A0A5S9X3X1
      Conserved Domains (1) summary
      PLN02434
      Location:1 → 237
      PLN02434; fatty acid hydroxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48916.1

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