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    NADP-ME1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816509, updated on 22-Aug-2024

    Summary

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    Official Symbol
    NADP-ME1
    Primary source
    Araport:AT2G19900
    Locus tag
    AT2G19900
    See related
    TAIR:AT2G19900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana NADP-malic enzyme 1; ATNADP-ME1; F6F22.7; F6F22_7; NADP-malic enzyme 1
    Summary
    The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME1 is expressed in response to developmental and cell-specific signals. The enzyme is active in vitro and appears to function as a homohexamer or homooctamer. It is believed to be a cytosolic protein.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    19
    Sequence:
    Chromosome: 2; NC_003071.7 (8591808..8595559, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Defensin-like (DEFL) family protein Neighboring gene miscRNA Neighboring gene RNA-dependent RNA polymerase family protein Neighboring gene RNA-dependent RNA polymerase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of function of Arabidopsis NADP-malic enzyme 1 results in enhanced tolerance to aluminum stress. Badia MB, et al. Plant J, 2020 Feb. PMID 31626366
    2. NADP-MALIC ENZYME 1 Affects Germination after Seed Storage in Arabidopsis thaliana. Yazdanpanah F, et al. Plant Cell Physiol, 2019 Feb 1. PMID 30388244
    3. A comprehensive analysis of the NADP-malic enzyme gene family of Arabidopsis. Wheeler MC, et al. Plant Physiol, 2005 Sep. PMID 16113210, Free PMC Article
    4. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of function of Arabidopsis NADP-malic enzyme 1 results in enhanced tolerance to aluminum stress.
      Title: Loss of function of Arabidopsis NADP-malic enzyme 1 results in enhanced tolerance to aluminum stress.
    2. Affects Germination after Seed Storage
      Title: NADP-MALIC ENZYME 1 Affects Germination after Seed Storage in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335646.1
    NM_127548.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within malate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    NADP-malic enzyme 1
    NP_179580.1
    • NADP-malic enzyme 1 (NADP-ME1); FUNCTIONS IN: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity, oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor, malic enzyme activity; INVOLVED IN: malate metabolic process, protein homooligomerization; LOCATED IN: cytosol; EXPRESSED IN: embryo, sperm cell, root, stamen, seed; EXPRESSED DURING: 4 anthesis, D bilateral stage; CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NADP-malic enzyme 3 (TAIR:AT5G25880.1); Has 9392 Blast hits to 9373 proteins in 2414 species: Archae - 143; Bacteria - 6244; Metazoa - 609; Fungi - 220; Plants - 469; Viruses - 0; Other Eukaryotes - 1707 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8591808..8595559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127548.4 → NP_179580.1  NADP-malic enzyme 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179580.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82191
      UniProtKB/TrEMBL
      A0A178VRX4, A0A5S9WZF0, A0A654EVX9
      Conserved Domains (1) summary
      PLN03129
      Location:4 → 581
      PLN03129; NADP-dependent malic enzyme; Provisional

    2. NM_001335646.1 → NP_001324890.1  NADP-malic enzyme 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1I3, A0A654EVX9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82191.1

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