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    dock11 dedicator of cytokinesis 11 [ Danio rerio (zebrafish) ]

    Gene ID: 799686, updated on 17-Aug-2024

    Summary

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    Official Symbol
    dock11provided by ZNC
    Official Full Name
    dedicator of cytokinesis 11provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-196
    See related
    Ensembl:ENSDARG00000062485 AllianceGenome:ZFIN:ZDB-GENE-060503-196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-150g2.3
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Orthologous to human DOCK11 (dedicator of cytokinesis 11). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See dock11 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (19179556..19332427, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (18927547..19080139, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene interleukin 13 receptor, alpha 1 Neighboring gene netrin 4 Neighboring gene small nuclear ribonucleoprotein polypeptide F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of Class I cytokine receptors. Liongue C, et al. BMC Evol Biol, 2007 Jul 18. PMID 17640376, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
      Title: Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202493.1 → NP_001189422.1  dedicator of cytokinesis protein 11

      Status: VALIDATED

      Source sequence(s)
      AL772340, CU571321
      UniProtKB/TrEMBL
      A0A0R4ILW7, A0A8M1P3L2
      Related
      ENSDARP00000135438.2, ENSDART00000169668.2
      Conserved Domains (5) summary
      cd08697
      Location:645 → 833
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11700
      Location:1610 → 2021
      DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
      cd13267
      Location:161 → 278
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:166 → 271
      PH; PH domain
      pfam11878
      Location:55 → 145
      DUF3398; Domain of unknown function (DUF3398)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      19179556..19332427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477617.1 → XP_021333292.1  dedicator of cytokinesis protein 11 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PP60
      Related
      ENSDARP00000084839.6, ENSDART00000090406.6
      Conserved Domains (4) summary
      cd08697
      Location:642 → 830
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11700
      Location:1607 → 2018
      DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
      cd13267
      Location:158 → 275
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:55 → 145
      DUF3398; Domain of unknown function (DUF3398)

    2. XM_009303084.3 → XP_009301359.1  dedicator of cytokinesis protein 11 isoform X1

      UniProtKB/Swiss-Prot
      A0A8M3BAW6, B0R034
      Related
      ENSDARP00000119904.3, ENSDART00000137575.5
      Conserved Domains (5) summary
      cd08697
      Location:642 → 830
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11700
      Location:1620 → 2031
      DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
      cd13267
      Location:158 → 275
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:163 → 268
      PH; PH domain
      pfam11878
      Location:55 → 145
      DUF3398; Domain of unknown function (DUF3398)

    3. XM_021477618.1 → XP_021333293.1  dedicator of cytokinesis protein 11 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q1V0
      Conserved Domains (4) summary
      cd08697
      Location:642 → 830
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11700
      Location:1620 → 2031
      DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
      cd13267
      Location:158 → 275
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:55 → 145
      DUF3398; Domain of unknown function (DUF3398)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394683.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      2548..69249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0R034.3 GenPept UniProtKB/Swiss-Prot:B0R034

    Gene LinkOut

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