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    mrtfaa myocardin related transcription factor Aa [ Danio rerio (zebrafish) ]

    Gene ID: 797480, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mrtfaaprovided by ZNC
    Official Full Name
    myocardin related transcription factor Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121205-3
    See related
    Ensembl:ENSDARG00000075867 AllianceGenome:ZFIN:ZDB-GENE-121205-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mkl1a
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and smooth muscle cell differentiation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mrtfaa in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (24694801..24768208)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (24564261..24634576)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene GTPase IMAP family member 7 Neighboring gene solute carrier family 25 member 17 Neighboring gene protein shisa-8 Neighboring gene desumoylating isopeptidase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smooth muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myocardin-related transcription factor A
    Names
    megakaryoblastic leukemia (translocation) 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      24694801..24768208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473680.2 → XP_021329355.1  myocardin-related transcription factor A isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q7Z3
      Conserved Domains (3) summary
      smart00707
      Location:97 → 122
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:396 → 429
      SAP; SAP domain
      pfam02755
      Location:143 → 163
      RPEL; RPEL repeat

    2. XM_021473674.2 → XP_021329349.1  myocardin-related transcription factor A isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q7Z3
      Related
      ENSDARP00000128445.1, ENSDART00000153507.2
      Conserved Domains (3) summary
      smart00707
      Location:97 → 122
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:396 → 429
      SAP; SAP domain
      pfam02755
      Location:143 → 163
      RPEL; RPEL repeat

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394532.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      172296..238982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299401.4 → XP_009297676.2  myocardin-related transcription factor A isoform X1

      UniProtKB/TrEMBL
      A0A8M9PXR9
      Conserved Domains (3) summary
      smart00707
      Location:97 → 122
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:396 → 429
      SAP; SAP domain
      pfam02755
      Location:143 → 163
      RPEL; RPEL repeat

    2. XM_009299400.4 → XP_009297675.2  myocardin-related transcription factor A isoform X1

      UniProtKB/TrEMBL
      A0A8M9PXR9
      Conserved Domains (3) summary
      smart00707
      Location:97 → 122
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:396 → 429
      SAP; SAP domain
      pfam02755
      Location:143 → 163
      RPEL; RPEL repeat

    3. XM_021471421.2 → XP_021327096.1  myocardin-related transcription factor A isoform X1

      UniProtKB/TrEMBL
      A0A8M9PXR9
      Conserved Domains (3) summary
      smart00707
      Location:97 → 122
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:396 → 429
      SAP; SAP domain
      pfam02755
      Location:143 → 163
      RPEL; RPEL repeat

    4. XM_068218103.1 → XP_068074204.1  myocardin-related transcription factor A isoform X1

    5. XM_068218104.1 → XP_068074205.1  myocardin-related transcription factor A isoform X2

    6. XM_068218105.1 → XP_068074206.1  myocardin-related transcription factor A isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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