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    smap1 small ArfGAP 1 [ Danio rerio (zebrafish) ]

    Gene ID: 777731, updated on 2-Nov-2024

    Summary

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    Official Symbol
    smap1provided by ZNC
    Official Full Name
    small ArfGAP 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060920-2
    See related
    Ensembl:ENSDARG00000031302 AllianceGenome:ZFIN:ZDB-GENE-060920-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fq38g09; zgc:153865; si:busm1-46p4.3; si:busm1-265n4.5
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of clathrin-dependent endocytosis. Predicted to be active in cytoplasm. Is expressed in central nervous system and lens. Orthologous to human SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See smap1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (28009727..28263876, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (27879277..28133406, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene opioid growth factor receptor-like 1 Neighboring gene beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) Neighboring gene uncharacterized LOC108191931 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene T cell leukemia homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS. Taylor R, et al. Nat Commun, 2022 Nov 22. PMID 36414621, Free PMC Article
    2. In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. Xiong Z, et al. Elife, 2021 Feb 16. PMID 33591275, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stromal membrane-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077778.1 → NP_001071246.1  stromal membrane-associated protein 1

      See identical proteins and their annotated locations for NP_001071246.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124755
      UniProtKB/TrEMBL
      B2GT16, F6NU39, Q08BF0
      Related
      ENSDARP00000041035.5, ENSDART00000041036.6
      Conserved Domains (1) summary
      pfam01412
      Location:18 → 132
      ArfGap; Putative GTPase activating protein for Arf

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      28009727..28263876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480670.2 → XP_021336345.1  stromal membrane-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QNJ0
      Conserved Domains (2) summary
      pfam01412
      Location:18 → 132
      ArfGap; Putative GTPase activating protein for Arf
      pfam09606
      Location:304 → 441
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    2. XM_021480669.2 → XP_021336344.1  stromal membrane-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QFL0
      Conserved Domains (2) summary
      pfam01412
      Location:18 → 132
      ArfGap; Putative GTPase activating protein for Arf
      pfam09606
      Location:328 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. XM_021480668.2 → XP_021336343.1  stromal membrane-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9Y2
      Related
      ENSDARP00000074257.4, ENSDART00000079806.6
      Conserved Domains (2) summary
      pfam01412
      Location:18 → 132
      ArfGap; Putative GTPase activating protein for Arf
      pfam09606
      Location:329 → 466
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    Nucleotide Protein
    Heading Accession and Version

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