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    Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 76650, updated on 2-Nov-2024

    Summary

    Official Symbol
    Srxn1provided by MGI
    Official Full Name
    sulfiredoxin 1 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:104971
    See related
    Ensembl:ENSMUSG00000032802 AllianceGenome:MGI:104971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Srx; Npn3; Srx1; TX01; 1700127B04Rik
    Summary
    Enables oxidoreductase activity, acting on a sulfur group of donors. Involved in response to oxidative stress. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adrenal medulla and embryo. Orthologous to human SRXN1 (sulfiredoxin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 100.0), adrenal adult (RPKM 95.3) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Srxn1 in Genome Data Viewer
    Location:
    2 G3; 2 74.83 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151946738..151953296)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152105524..152111376)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene scratch family zinc finger 2 Neighboring gene STARR-seq mESC enhancer starr_06043 Neighboring gene predicted gene, 31475 Neighboring gene predicted gene, 31535 Neighboring gene transcription factor 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on a sulfur group of donors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxidoreductase activity, acting on a sulfur group of donors ISO
    Inferred from Sequence Orthology
    more info
     
    enables sulfiredoxin activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    sulfiredoxin-1
    Names
    neoplastic progression 3
    neoplastic progression protein 3
    XP_036018567.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029688.6NP_083964.3  sulfiredoxin-1

      Status: VALIDATED

      Source sequence(s)
      AL845161
      Consensus CDS
      CCDS16877.2
      UniProtKB/Swiss-Prot
      Q3TWN6, Q91VN5, Q9D975
      Related
      ENSMUSP00000046196.8, ENSMUST00000041500.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      151946738..151953296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162674.1XP_036018567.1  sulfiredoxin-1 isoform X1

      UniProtKB/TrEMBL
      A2AQU8
      Conserved Domains (1) summary
      cd16395
      Location:59148
      Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation