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    Cdyl2 chromodomain protein, Y chromosome-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 75796, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdyl2provided by MGI
    Official Full Name
    chromodomain protein, Y chromosome-like 2provided by MGI
    Primary source
    MGI:MGI:1923046
    See related
    Ensembl:ENSMUSG00000031758 AllianceGenome:MGI:1923046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm20194; 1700029M19Rik; 4930453I21Rik
    Summary
    Enables methylated histone binding activity. Located in nucleus. Orthologous to human CDYL2 (chromodomain Y like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 1.6), thymus adult (RPKM 1.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdyl2 in Genome Data Viewer
    Location:
    8 E1; 8 63.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117295462..117459730, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (116568723..116732991, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:119028691-119028992 Neighboring gene STARR-seq mESC enhancer starr_22798 Neighboring gene dynein light chain roadblock-type 2 Neighboring gene predicted gene, 39258 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119111671-119111780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119114162-119114494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119114548-119114808 Neighboring gene predicted gene, 31367 Neighboring gene STARR-positive B cell enhancer mm9_chr8:119159393-119159693 Neighboring gene STARR-seq mESC enhancer starr_22801 Neighboring gene STARR-positive B cell enhancer ABC_E8265 Neighboring gene STARR-positive B cell enhancer ABC_E6689 Neighboring gene RIKEN cDNA 4930563M20 gene Neighboring gene translation machinery-associated protein 7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs. Fischle W, et al. J Biol Chem, 2008 Jul 11. PMID 18450745, Free PMC Article
    2. CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice. Okashita N, et al. Proc Natl Acad Sci U S A, 2023 May 16. PMID 37155872, Free PMC Article
    3. The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Dorus S, et al. Hum Mol Genet, 2003 Jul 15. PMID 12837688
    4. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromodomain Y-like protein 2
    Names
    CDY-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029441.3 → NP_083717.1  chromodomain Y-like protein 2

      See identical proteins and their annotated locations for NP_083717.1

      Status: VALIDATED

      Source sequence(s)
      AC112969, BC058956
      Consensus CDS
      CCDS40488.1
      UniProtKB/Swiss-Prot
      Q9D5D8
      UniProtKB/TrEMBL
      Q3UQV4, Q7TQ22
      Related
      ENSMUSP00000104730.3, ENSMUST00000109102.4
      Conserved Domains (2) summary
      cd06558
      Location:249 → 445
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      cd18634
      Location:6 → 57
      CD_CDY; chromodomain of the Chromodomain Y-like protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      117295462..117459730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312996.3 → XP_017168485.1  chromodomain Y-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q9CVU3
      Conserved Domains (1) summary
      cd06558
      Location:106 → 302
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D5D8.1 GenPept UniProtKB/Swiss-Prot:Q9D5D8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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