uraha urate (5-hydroxyiso-) hydrolase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: urahaprovided by ZNC
Official Full Name: urate (5-hydroxyiso-) hydrolase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060825-253
See related: Ensembl:ENSDARG00000100719 AllianceGenome:ZFIN:ZDB-GENE-060825-253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: urah; zgc:153543
Summary: Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and hydroxyisourate hydrolase activity. Acts upstream of or within purine nucleobase metabolic process. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (31016296..31023447)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (31038042..31045193)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This review cites the remarkable changes of HIUase active sites during the evolution of transthyretin that gave rise to a channel open at both ends, thus allowing free access to hormone molecules.
Title: Structure of zebra fish HIUase: insights into evolution of an enzyme to a hormone transporter.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydroxyisourate hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydroxyisourate hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in purine nucleobase metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine nucleobase metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleobase metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in urate catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: 5-hydroxyisourate hydrolase

Names: HIU hydrolase; HIUHase; transthyretin-related protein

NP_001038917.2

EC 3.5.2.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045452.2 → NP_001038917.2 5-hydroxyisourate hydrolase

See identical proteins and their annotated locations for NP_001038917.2

Status: VALIDATED

Source sequence(s)

BC095750, EH526856

UniProtKB/Swiss-Prot

Q06S87, Q0P422

UniProtKB/TrEMBL

A0A0R4IGA6, A0A8M1NB09

Related

ENSDARP00000132931.1, ENSDART00000172461.2

Conserved Domains (1) summary

cd05469
Location:26 → 138

Transthyretin_like; Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins ...