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    Magec2 MAGE family member C2 [ Mus musculus (house mouse) ]

    Gene ID: 74437, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Magec2provided by MGI
    Official Full Name
    MAGE family member C2provided by MGI
    Primary source
    MGI:MGI:1921687
    See related
    Ensembl:ENSMUSG00000045330 AllianceGenome:MGI:1921687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933402E13Rik
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in cranial ganglion and lung. Orthologous to human MAGEC1 (MAGE family member C1) and MAGEC2 (MAGE family member C2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 43.6) See more
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    Genomic context

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    See Magec2 in Genome Data Viewer
    Location:
    X A6; X 34.57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (61326566..61335690)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (62282960..62292084)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene melanoma antigen family A pseudogene Neighboring gene STARR-seq mESC enhancer starr_47257 Neighboring gene STARR-seq mESC enhancer starr_47258 Neighboring gene N-myristoyltransferase 1 pseudogene Neighboring gene RIKEN cDNA 4931400O07 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Garcia TX, et al. Development, 2014 Dec. PMID 25406395, Free PMC Article
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen 11-like
    Names
    Novel transcript similar to melanoma-associated antigen 11 (MAGE-11 antigen)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199996.1 → NP_001186925.1  melanoma-associated antigen 11-like

      See identical proteins and their annotated locations for NP_001186925.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK016614
      Consensus CDS
      CCDS53078.1
      UniProtKB/TrEMBL
      Q9D4D2
      Related
      ENSMUSP00000056260.2, ENSMUST00000051414.2
      Conserved Domains (1) summary
      pfam01454
      Location:224 → 379
      MAGE; MAGE family

    2. NM_001199997.1 → NP_001186926.1  melanoma-associated antigen 11-like

      See identical proteins and their annotated locations for NP_001186926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL831775, BY074679
      Consensus CDS
      CCDS53078.1
      UniProtKB/TrEMBL
      Q9D4D2
      Related
      ENSMUSP00000136235.2, ENSMUST00000178085.8
      Conserved Domains (1) summary
      pfam01454
      Location:224 → 379
      MAGE; MAGE family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      61326566..61335690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528321.2 → XP_006528384.1  melanoma-associated antigen 11-like isoform X1

      See identical proteins and their annotated locations for XP_006528384.1

      UniProtKB/TrEMBL
      Q9D4D2
      Conserved Domains (1) summary
      pfam01454
      Location:224 → 379
      MAGE; MAGE family
    Nucleotide Protein Strain
    Heading Accession and Version

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