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    Baiap2l2 BAR/IMD domain containing adaptor protein 2 like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685357, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Baiap2l2provided by RGD
    Official Full Name
    BAR/IMD domain containing adaptor protein 2 like 2provided by RGD
    Primary source
    RGD:1595091
    See related
    EnsemblRapid:ENSRNOG00000012215 AllianceGenome:RGD:1595091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308786
    Summary
    Predicted to enable identical protein binding activity and phospholipid binding activity. Predicted to be involved in actin filament organization; membrane organization; and positive regulation of actin filament polymerization. Predicted to be located in cell-cell contact zone and vesicle membrane. Predicted to be part of clathrin complex. Predicted to be active in cytosol and nucleoplasm. Orthologous to human BAIAP2L2 (BAR/IMD domain containing adaptor protein 2 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 145.0) and Thymus (RPKM 7.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Baiap2l2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112704798..112731691, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110824370..110850702, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120492366..120518803, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479937 Neighboring gene protein interacting with PRKCA 1 Neighboring gene solute carrier family 16 member 8 Neighboring gene phospholipase A2 group VI Neighboring gene MAF bZIP transcription factor F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Pykäläinen A, et al. Nat Struct Mol Biol, 2011 Jul 10. PMID 21743456, Free PMC Article
    2. Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. Veltman DM, et al. Biochem J, 2011 May 15. PMID 21401524
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
    Names
    BAI1-associated protein 2-like 2
    rCG60233-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271220.1 → NP_001258149.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001258149.1

      Status: VALIDATED

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HSR1, D4A901
      Related
      ENSRNOP00000016362.6, ENSRNOT00000016362.7
      Conserved Domains (2) summary
      cd07644
      Location:6 → 220
      I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cd11914
      Location:327 → 385
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

    2. NM_001402152.1 → NP_001389081.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000110704.1, ENSRNOT00000157580.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112704798..112731691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264259.1 → XP_063120329.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X4

    2. XM_039079895.2 → XP_038935823.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X2

      Conserved Domains (3) summary
      cd11914
      Location:319 → 377
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      PHA03247
      Location:229 → 542
      PHA03247; large tegument protein UL36; Provisional
      cl12013
      Location:85 → 212
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_039079898.2 → XP_038935826.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X5

      Conserved Domains (2) summary
      cd11914
      Location:319 → 377
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cl12013
      Location:85 → 212
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_039079894.2 → XP_038935822.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X1

      Conserved Domains (3) summary
      cd11914
      Location:319 → 377
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      PHA03247
      Location:229 → 549
      PHA03247; large tegument protein UL36; Provisional
      cl12013
      Location:85 → 212
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_063264260.1 → XP_063120330.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X6

      Related
      ENSRNOP00000102407.1, ENSRNOT00000134704.1

    6. XM_039079897.2 → XP_038935825.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

      Conserved Domains (2) summary
      cd11914
      Location:224 → 282
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cl12013
      Location:1 → 117
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_005486728.2 RNA Sequence

    2. XR_010053042.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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