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    Gar1 GAR1 ribonucleoprotein [ Mus musculus (house mouse) ]

    Gene ID: 68147, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gar1provided by MGI
    Official Full Name
    GAR1 ribonucleoproteinprovided by MGI
    Primary source
    MGI:MGI:1930948
    See related
    Ensembl:ENSMUSG00000028010 AllianceGenome:MGI:1930948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nola1; C430047J18Rik
    Summary
    Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Predicted to be involved in snoRNA guided rRNA pseudouridine synthesis and telomere maintenance via telomerase. Predicted to be located in dense fibrillar component; fibrillar center; and nucleoplasm. Predicted to be part of box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human GAR1 (GAR1 ribonucleoprotein). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in liver E14 (RPKM 26.6), CNS E11.5 (RPKM 25.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gar1 in Genome Data Viewer
    Location:
    3 G3; 3 59.16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129618561..129625045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129824912..129831407, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene predicted gene, 36130 Neighboring gene retinal pigment epithelium derived rhodopsin homolog Neighboring gene STARR-positive B cell enhancer ABC_E7942 Neighboring gene predicted gene, 36180 Neighboring gene complement component factor i Neighboring gene phospholipase A2, group XIIA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Pogacić V, et al. Mol Cell Biol, 2000 Dec. PMID 11074001, Free PMC Article
    2. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Egan ED, et al. Mol Cell Biol, 2010 Jun. PMID 20351177, Free PMC Article
    3. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. Kappei D, et al. EMBO J, 2013 Jun 12. PMID 23685356, Free PMC Article
    4. Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis. Mikula M, et al. Proteome Sci, 2015. PMID 26336360, Free PMC Article
    5. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables box H/ACA snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables box H/ACA snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables telomerase RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snoRNA guided rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snoRNA guided rRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomerase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in telomere maintenance via telomerase NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of box H/ACA snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of box H/ACA telomerase RNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of box H/ACA telomerase RNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dense fibrillar component ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of telomerase holoenzyme complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    H/ACA ribonucleoprotein complex subunit 1
    Names
    GAR1 ribonucleoprotein homolog
    H/ACA small nucleolar RNPs
    nucleolar protein family A member 1
    nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)
    snoRNP protein GAR1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429088.1 → NP_001416017.1  H/ACA ribonucleoprotein complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      AC111097
      UniProtKB/Swiss-Prot
      Q80X93, Q8C6C5, Q8VDH0, Q9CY66

    2. NM_026578.4 → NP_080854.1  H/ACA ribonucleoprotein complex subunit 1

      See identical proteins and their annotated locations for NP_080854.1

      Status: VALIDATED

      Source sequence(s)
      AC111097
      Consensus CDS
      CCDS38634.1
      UniProtKB/Swiss-Prot
      Q80X93, Q8C6C5, Q8VDH0, Q9CY66
      UniProtKB/TrEMBL
      Q3TKG5
      Related
      ENSMUSP00000029643.9, ENSMUST00000029643.15
      Conserved Domains (1) summary
      pfam04410
      Location:72 → 170
      Gar1; Gar1/Naf1 RNA binding region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      129618561..129625045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240208.4 → XP_011238510.1  H/ACA ribonucleoprotein complex subunit 1 isoform X1

      Conserved Domains (1) summary
      pfam04410
      Location:72 → 170
      Gar1; Gar1/Naf1 RNA binding region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY66.1 GenPept UniProtKB/Swiss-Prot:Q9CY66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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