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    Gstcd glutathione S-transferase, C-terminal domain containing [ Mus musculus (house mouse) ]

    Gene ID: 67553, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gstcdprovided by MGI
    Official Full Name
    glutathione S-transferase, C-terminal domain containingprovided by MGI
    Primary source
    MGI:MGI:1914803
    See related
    Ensembl:ENSMUSG00000028018 AllianceGenome:MGI:1914803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933434L15Rik
    Summary
    Predicted to be active in cytoplasm. Is expressed in ductus deferens and testis. Orthologous to human GSTCD (glutathione S-transferase C-terminal domain containing). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.0), testis adult (RPKM 6.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gstcd in Genome Data Viewer
    Location:
    3 G3; 3 61.54 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (132687511..132797800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (132981750..133092039, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09020 Neighboring gene predicted gene, 29811 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene nephronectin Neighboring gene predicted gene, 23196 Neighboring gene TIP41, TOR signalling pathway regulator-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6130 Neighboring gene STARR-positive B cell enhancer ABC_E9573 Neighboring gene STARR-positive B cell enhancer mm9_chr3:132754721-132755022 Neighboring gene STARR-positive B cell enhancer ABC_E11218 Neighboring gene integrator complex subunit 12 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene STARR-seq mESC enhancer starr_09022 Neighboring gene predicted gene, 52616 Neighboring gene STARR-positive B cell enhancer ABC_E10215 Neighboring gene STARR-positive B cell enhancer ABC_E4594 Neighboring gene STARR-positive B cell enhancer ABC_E4595 Neighboring gene STARR-positive B cell enhancer ABC_E9574 Neighboring gene STARR-seq mESC enhancer starr_09023 Neighboring gene pyrophosphatase (inorganic) 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice. Liu B, et al. PLoS One, 2019. PMID 31513609, Free PMC Article
    2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC74393

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase C-terminal domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356309.1 → NP_001343238.1  glutathione S-transferase C-terminal domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AC124593, BC061240
      Consensus CDS
      CCDS17847.1
      UniProtKB/Swiss-Prot
      Q5RL51, Q6P8I1, Q8BXR2, Q8BYY6, Q9CTV2, Q9CUA9, Q9CXU7
      Related
      ENSMUSP00000079421.6, ENSMUST00000080583.6
      Conserved Domains (2) summary
      cl02776
      Location:271 → 330
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:424 → 542
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_026231.3 → NP_080507.2  glutathione S-transferase C-terminal domain-containing protein

      See identical proteins and their annotated locations for NP_080507.2

      Status: VALIDATED

      Source sequence(s)
      AC124593, BC047136, BY740821
      Consensus CDS
      CCDS17847.1
      UniProtKB/Swiss-Prot
      Q5RL51, Q6P8I1, Q8BXR2, Q8BYY6, Q9CTV2, Q9CUA9, Q9CXU7
      Related
      ENSMUSP00000029651.5, ENSMUST00000029651.11
      Conserved Domains (2) summary
      cl02776
      Location:271 → 330
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:424 → 542
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      132687511..132797800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003954372.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RL51.1 GenPept UniProtKB/Swiss-Prot:Q5RL51

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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