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    Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain [ Mus musculus (house mouse) ]

    Gene ID: 66885, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Acadsbprovided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase, short/branched chainprovided by MGI
    Primary source
    MGI:MGI:1914135
    See related
    Ensembl:ENSMUSG00000030861 AllianceGenome:MGI:1914135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SBCAD; 2-MEBCAD; 1300003O09Rik
    Summary
    Predicted to enable electron transfer activity; identical protein binding activity; and short-chain 2-methyl fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid metabolic process and isoleucine catabolic process. Predicted to act upstream of or within acyl-CoA metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 14.5), subcutaneous fat pad adult (RPKM 14.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acadsb in Genome Data Viewer
    Location:
    7 F3; 7 74.03 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (131012330..131047940)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131410601..131446211)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310057M21 gene Neighboring gene STARR-positive B cell enhancer ABC_E9713 Neighboring gene STARR-positive B cell enhancer ABC_E8214 Neighboring gene STARR-seq mESC enhancer starr_20280 Neighboring gene phosphoseryl-tRNA kinase Neighboring gene STARR-seq mESC enhancer starr_20281 Neighboring gene IKAROS family zinc finger 5 Neighboring gene STARR-positive B cell enhancer ABC_E4981 Neighboring gene motile sperm domain containing 3 pseudogene Neighboring gene predicted gene, 39099

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p. Zhang P, et al. Genes (Basel), 2021 Apr 17. PMID 33920575, Free PMC Article
    2. Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. Peng MZ, et al. Cell Mol Life Sci, 2022 Jun 21. PMID 35727412, Free PMC Article
    3. PPARα-Target Gene Expression Requires TIS21(/BTG2) Gene in Liver of the C57BL/6 Mice under Fasting Condition. Hong AE, et al. Mol Cells, 2018 Feb 28. PMID 29385670, Free PMC Article
    4. eXPRESSION: an in silico tool to predict patterns of gene expression. Ferguson DA, et al. Gene Expr Patterns, 2005 Jun. PMID 15939374
    5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.
      Title: LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables short-chain 2-methyl fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables short-chain 2-methyl fatty acyl-CoA dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables short-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables short-chain fatty acyl-CoA dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in isoleucine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoleucine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    2-methyl branched chain acyl-CoA dehydrogenase
    2-methylbutyryl-coenzyme A dehydrogenase
    NP_080102.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025826.4 → NP_080102.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_080102.1

      Status: VALIDATED

      Source sequence(s)
      AK004889, AW987640, BY296718
      Consensus CDS
      CCDS21916.1
      UniProtKB/Swiss-Prot
      Q9DBL1
      UniProtKB/TrEMBL
      Q7TMY2
      Related
      ENSMUSP00000015829.8, ENSMUST00000015829.15
      Conserved Domains (2) summary
      cd01158
      Location:59 → 430
      SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
      COG1960
      Location:57 → 428
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      131012330..131047940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003946541.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBL1.1 GenPept UniProtKB/Swiss-Prot:Q9DBL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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