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    Tmt1a3 thiol methyltransferase 1A3 [ Mus musculus (house mouse) ]

    Gene ID: 668178, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tmt1a3provided by MGI
    Official Full Name
    thiol methyltransferase 1A3provided by MGI
    Primary source
    MGI:MGI:3710670
    See related
    Ensembl:ENSMUSG00000058057 AllianceGenome:MGI:3710670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubie3; Gm10035; Mettl7a3
    Summary
    Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in kidney adult (RPKM 17.8), colon adult (RPKM 2.7) and 2 other tissues See more
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    Genomic context

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    See Tmt1a3 in Genome Data Viewer
    Location:
    15 F1; 15 56.27 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100232687..100246267)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100334806..100348386)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33666 Neighboring gene STARR-positive B cell enhancer ABC_E9423 Neighboring gene predicted gene, 53910 Neighboring gene thiol methyltransferase 1A1 Neighboring gene methyltransferase hypoxia inducible domain containing 1 Neighboring gene thiol methyltransferase 1A2 Neighboring gene HIG1 domain family, member 1C Neighboring gene predicted gene, 53911

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA m(6)A methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiol S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lncRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UbiE3 protein; ubiE3 protein
    Names
    methyltransferase like 7A3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081471.1 → NP_001074940.1  UbiE3 protein

      See identical proteins and their annotated locations for NP_001074940.1

      Status: VALIDATED

      Source sequence(s)
      AB253945, AC124479
      Consensus CDS
      CCDS37209.1
      UniProtKB/TrEMBL
      G3X9G9, Q76I24
      Related
      ENSMUSP00000074875.5, ENSMUST00000075420.6
      Conserved Domains (1) summary
      pfam08241
      Location:75 → 172
      Methyltransf_11; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100232687..100246267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245712.3 → XP_011244014.1  ubiE3 protein isoform X2

      UniProtKB/TrEMBL
      H3BJI7
      Conserved Domains (1) summary
      pfam08241
      Location:75 → 166
      Methyltransf_11; Methyltransferase domain

    2. XM_006521279.5 → XP_006521342.1  ubiE3 protein isoform X1

      See identical proteins and their annotated locations for XP_006521342.1

      UniProtKB/TrEMBL
      Q76I24
      Conserved Domains (1) summary
      pfam08241
      Location:78 → 139
      Methyltransf_11; Methyltransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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