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    mibp muscle-specific beta 1 integrin binding protein [ Danio rerio (zebrafish) ]

    Gene ID: 64674, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mibpprovided by ZNC
    Official Full Name
    muscle-specific beta 1 integrin binding proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030404-1
    See related
    Ensembl:ENSDARG00000101362 AllianceGenome:ZFIN:ZDB-GENE-030404-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    urk; cb1024
    Summary
    Predicted to enable ribosylnicotinamide kinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; nervous system; neural plate; proliferative region; and ventral mesoderm. Orthologous to human NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mibp in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (5118313..5122557)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (4733938..4738182)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene zinc finger RNA binding protein 2 Neighboring gene ATCAY kinesin light chain interacting caytaxin a Neighboring gene lysyl oxidase-like 5a Neighboring gene uncharacterized LOC101884287 Neighboring gene myeloid-derived growth factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hypoxia induces myocardial regeneration in zebrafish. Jopling C, et al. Circulation, 2012 Dec 18. PMID 23151342
    2. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Rawls JF, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070763, Free PMC Article
    3. Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Macaulay IC, et al. Cell Rep, 2016 Feb 2. PMID 26804912, Free PMC Article
    4. prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish. Wang Y, et al. J Genet Genomics, 2018 Aug 20. PMID 30174136
    5. Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. Sullivan C, et al. PLoS One, 2017. PMID 28658311, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosylnicotinamide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    muscle-specific beta 1 integrin binding protein
    Names
    nicotinamide riboside kinase 2
    uridine kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131693.2 → NP_571768.2  muscle-specific beta 1 integrin binding protein

      See identical proteins and their annotated locations for NP_571768.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      CR936300, EH550773
      UniProtKB/TrEMBL
      A0A8M6Z3E8, Q7ZW81
      Related
      ENSDARP00000137169.1, ENSDART00000168371.2
      Conserved Domains (1) summary
      cd02024
      Location:4 → 170
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    RNA

    1. NR_102288.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CR936300
      Related
      ENSDART00000170222.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      5118313..5122557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353192.3 → XP_017208681.1  muscle-specific beta 1 integrin binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z3E8, Q7ZW81
      Conserved Domains (1) summary
      cd02024
      Location:4 → 170
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    2. XM_017353193.3 → XP_017208682.1  muscle-specific beta 1 integrin binding protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4ISM1, A0A8M6YVG8
      Related
      ENSDARP00000137417.1, ENSDART00000169200.2
    Nucleotide Protein Strain
    Heading Accession and Version

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