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    sh3d21 SH3 domain containing 21 [ Danio rerio (zebrafish) ]

    Gene ID: 641492, updated on 28-Oct-2024

    Summary

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    Official Symbol
    sh3d21provided by ZNC
    Official Full Name
    SH3 domain containing 21provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051120-57
    See related
    Ensembl:ENSDARG00000099448 AllianceGenome:ZFIN:ZDB-GENE-051120-57
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:123285
    Summary
    Predicted to be involved in actin filament organization and cell migration. Is expressed in corneal epithelium. Orthologous to human SH3D21 (SH3 domain containing 21). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sh3d21 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (35905031..35938157)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (35952136..35985282)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487938 Neighboring gene thyroid hormone receptor associated protein 3a Neighboring gene eva-1 homolog Ba (C. elegans) Neighboring gene serine/threonine kinase 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber. Takamiya M, et al. PLoS One, 2015. PMID 25692557, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123285

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037432.2 → NP_001032509.2  SH3 domain-containing protein 21

      Status: VALIDATED

      Source sequence(s)
      BX321921
      UniProtKB/TrEMBL
      A0A0R4IK14, A0A8M1N8B2
      Related
      ENSDARP00000135563.1, ENSDART00000162411.2
      Conserved Domains (4) summary
      cd11873
      Location:2 → 55
      SH3_CD2AP-like_1; First Src Homology 3 domain (SH3A) of CD2-associated protein and similar proteins
      cd11874
      Location:83 → 135
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:177 → 231
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      pfam09798
      Location:377 → 411
      LCD1; DNA damage checkpoint protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      35905031..35938157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158311.5 → XP_005158368.1  SH3 domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B585
      Conserved Domains (5) summary
      cd11873
      Location:2 → 55
      SH3_CD2AP-like_1; First Src Homology 3 domain (SH3A) of CD2-associated protein and similar proteins
      cd11874
      Location:83 → 135
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:177 → 231
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      pfam09798
      Location:449 → 483
      LCD1; DNA damage checkpoint protein
      pfam10267
      Location:407 → 494
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. XM_005158312.5 → XP_005158369.1  SH3 domain-containing protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B567
      Conserved Domains (5) summary
      cd11873
      Location:2 → 55
      SH3_CD2AP-like_1; First Src Homology 3 domain (SH3A) of CD2-associated protein and similar proteins
      cd11874
      Location:83 → 135
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:177 → 231
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      pfam09798
      Location:426 → 460
      LCD1; DNA damage checkpoint protein
      pfam10267
      Location:357 → 471
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. XM_005158313.5 → XP_005158370.1  SH3 domain-containing protein 21 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B4P5
      Conserved Domains (5) summary
      cd11873
      Location:2 → 55
      SH3_CD2AP-like_1; First Src Homology 3 domain (SH3A) of CD2-associated protein and similar proteins
      cd11874
      Location:83 → 135
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:177 → 231
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      pfam09798
      Location:400 → 434
      LCD1; DNA damage checkpoint protein
      pfam10267
      Location:358 → 445
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    Nucleotide Protein
    Heading Accession and Version

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