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    SLO2 slowpoke 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740325, updated on 2-Nov-2024

    Summary

    Official Symbol
    SLO2provided by FlyBase
    Official Full Name
    slowpoke 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0261698
    Locus tag
    Dmel_CG42732
    See related
    AllianceGenome:FB:FBgn0261698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12897; CG12899; CG12901; CG12904; CG34363; CG42732; Dmel\CG42732; Dm_2R:24301; Dm_2R:24438; dSlo2; dSLO2; Slack; Slo2
    Old locus tag
    CG12899; CG12904; Dmel_CG12897; Dmel_CG12899; Dmel_CG12904; Dmel_CG34363
    Summary
    Enables intracellular sodium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See SLO2 in Genome Data Viewer
    Location:
    47A1-47A7; 2-62 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10322195..10416996, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6209700..6304501, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 46a Neighboring gene uncharacterized protein Neighboring gene Nidogen Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 47a Neighboring gene Ionotropic receptor 47b Neighboring gene Ionotropic receptor 47a Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6c

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables intracellular sodium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables intracellular sodium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    slowpoke 2
    Names
    CG42732-PD
    CG42732-PE
    CG42732-PF
    CG42732-PG
    CG42732-PH
    CG42732-PI
    CG42732-PL
    CG42732-PN
    CG42732-PO
    SLO2-PD
    SLO2-PE
    SLO2-PF
    SLO2-PG
    SLO2-PH
    SLO2-PI
    SLO2-PL
    SLO2-PN
    SLO2-PO

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10322195..10416996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273934.1NP_001260863.1  slowpoke 2, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF87
      Conserved Domains (2) summary
      pfam03493
      Location:507602
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:302346
      Ion_trans_2; Ion channel
    2. NM_001273933.1NP_001260862.1  slowpoke 2, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFK3
      Conserved Domains (2) summary
      pfam03493
      Location:461556
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:256300
      Ion_trans_2; Ion channel
    3. NM_001259313.2NP_001246242.1  slowpoke 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K738, A0A165TJ88
      Conserved Domains (2) summary
      pfam03493
      Location:457552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252296
      Ion_trans_2; Ion channel
    4. NM_001201972.3NP_001188901.1  slowpoke 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHC4
      Conserved Domains (2) summary
      pfam03493
      Location:457552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252296
      Ion_trans_2; Ion channel
    5. NM_001273932.1NP_001260861.1  slowpoke 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260861.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEQ3
      Conserved Domains (2) summary
      pfam03493
      Location:457552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252296
      Ion_trans_2; Ion channel
    6. NM_001273935.1NP_001260864.1  slowpoke 2, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEJ9
      Conserved Domains (2) summary
      pfam03493
      Location:457552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252296
      Ion_trans_2; Ion channel
    7. NM_001103788.3NP_001097258.2  slowpoke 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097258.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY94
      Conserved Domains (2) summary
      pfam03493
      Location:524619
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:297363
      Ion_trans_2; Ion channel
    8. NM_001103789.3NP_001097259.2  slowpoke 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097259.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY93
      Conserved Domains (2) summary
      pfam03493
      Location:524619
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:297363
      Ion_trans_2; Ion channel
    9. NM_001201971.2NP_001188900.1  slowpoke 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188900.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD38
      Conserved Domains (2) summary
      pfam03493
      Location:538633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:311377
      Ion_trans_2; Ion channel