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    ark2ca arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2Ca [ Danio rerio (zebrafish) ]

    Gene ID: 572251, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ark2caprovided by ZNC
    Official Full Name
    arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2Caprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091118-64
    See related
    Ensembl:ENSDARG00000077906 AllianceGenome:ZFIN:ZDB-GENE-091118-64
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rnf165a; si:ch73-29c22.3
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be active in nucleus. Orthologous to human ARK2C (arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ark2ca in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (4965124..5007180, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (4809099..4842669, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:ch73-29c22.1 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene arkadia (rnf111) N-terminal like PKA signaling regulator 2n Neighboring gene HAUS augmin-like complex, subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARK2C
    Names
    ring finger protein 165a
    rnf165

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      4965124..5007180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160989.5 → XP_005161046.1  E3 ubiquitin-protein ligase ARK2C isoform X2

      UniProtKB/TrEMBL
      A0A8M2B7X4, E9QHW9
      Related
      ENSDARP00000088568.4, ENSDART00000097796.5
      Conserved Domains (1) summary
      pfam13639
      Location:259 → 300
      zf-RING_2; Ring finger domain

    2. XM_017352857.3 → XP_017208346.1  E3 ubiquitin-protein ligase ARK2C isoform X1

      UniProtKB/TrEMBL
      A0A8M6YUK5

    3. XM_068215967.1 → XP_068072068.1  E3 ubiquitin-protein ligase ARK2C isoform X3

    Nucleotide Protein
    Heading Accession and Version

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