pglyrp6 peptidoglycan recognition protein 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pglyrp6provided by ZNC
Official Full Name: peptidoglycan recognition protein 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-071227-2
See related: Ensembl:ENSDARG00000103642 AllianceGenome:ZFIN:ZDB-GENE-071227-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables N-acetylmuramoyl-L-alanine amidase activity. Acts upstream of or within defense response to bacterium. Predicted to be located in membrane. Is expressed in several structures, including acinar cell; gill lamella; gut absorptive cell; liver; and pleuroperitoneal region. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (13624815..13633331)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (13474969..13483485)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identified and cloned three zebrafish Peptidoglycan recognition proteins, PGLYRP-2, PGLYRP-5, and PGLYRP-6, and showed that they are highly expressed in eggs, developing embryos, and adult tissues that contact external environment
Title: Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan immune receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidoglycan recognition protein 6

Names: zfPGRP6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045222.2 → NP_001038687.2 peptidoglycan recognition protein 6

Status: VALIDATED

Source sequence(s)

BC171349, CU929085

UniProtKB/TrEMBL

A0A0R4IJX9, A0A8M1NA85, B7ZUU1

Related

ENSDARP00000136160.1, ENSDART00000161451.2

Conserved Domains (1) summary

smart00701
Location:328 → 472

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme