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    arap1a ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1a [ Danio rerio (zebrafish) ]

    Gene ID: 571767, updated on 2-Nov-2024

    Summary

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    Official Symbol
    arap1aprovided by ZNC
    Official Full Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6226
    See related
    Ensembl:ENSDARG00000062221 AllianceGenome:ZFIN:ZDB-GENE-030131-6226
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi39f07; wu:fi39f07; si:ch211-135f11.1
    Summary
    Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of actin cytoskeleton organization and regulation of cell projection organization. Predicted to act upstream of or within positive regulation of GTPase activity and signal transduction. Predicted to be active in cytoplasm. Orthologous to human ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See arap1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23888307..23909945, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23384160..23406170, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 3 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 6 Neighboring gene excision repair cross-complementation group 6-like Neighboring gene uncharacterized LOC137495586

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell projection organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      23888307..23909945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_695389.9 → XP_700481.5  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

      UniProtKB/TrEMBL
      A0A8N7TBX5
      Related
      ENSDARP00000123586.3, ENSDART00000142516.5
      Conserved Domains (5) summary
      cd04385
      Location:665 → 845
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      pfam00169
      Location:56 → 147
      PH; PH domain
      pfam01412
      Location:266 → 378
      ArfGap; Putative GTPase activating protein for Arf
      cl00155
      Location:887 → 968
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:463 → 566
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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