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    dock5 dedicator of cytokinesis 5 [ Danio rerio (zebrafish) ]

    Gene ID: 571688, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dock5provided by ZNC
    Official Full Name
    dedicator of cytokinesis 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080108-4
    See related
    Ensembl:ENSDARG00000001968 AllianceGenome:ZFIN:ZDB-GENE-080108-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within myoblast fusion. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human DOCK5 (dedicator of cytokinesis 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dock5 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (6645830..6825663, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (6607705..6782040, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 8b Neighboring gene uncharacterized LOC101885047 Neighboring gene taste receptor, type 2, member 202 Neighboring gene uncharacterized LOC137496290 Neighboring gene neurofilament medium chain b Neighboring gene neurofilament light chain b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion. Moore CA, et al. Development, 2007 Sep. PMID 17670792
    2. NEFLb impairs early nervous system development via regulation of neuron apoptosis in zebrafish. Wang S, et al. J Cell Physiol, 2019 Jul. PMID 30569449
    3. L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Hsu PJ, et al. J Biomed Sci, 2021 Jan 12. PMID 33435938, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The fusion of embryonic fast-twitch myoblasts requires the activities of Dock1 and the closely related Dock5 protein.
      Title: A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myoblast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110012.1 → NP_001103482.1  dedicator of cytokinesis protein 5

      See identical proteins and their annotated locations for NP_001103482.1

      Status: PROVISIONAL

      Source sequence(s)
      AM888371
      UniProtKB/TrEMBL
      A8E1V7
      Related
      ENSDARP00000123474.1, ENSDART00000135834.3
      Conserved Domains (4) summary
      cd12051
      Location:12 → 67
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:71 → 434
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1235 → 1634
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
      cl14603
      Location:442 → 636
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      6645830..6825663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223015.1 → XP_068079116.1  dedicator of cytokinesis protein 5 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.