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    srgap1a SLIT-ROBO Rho GTPase activating protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 570262, updated on 12-Sep-2024

    Summary

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    Official Symbol
    srgap1aprovided by ZNC
    Official Full Name
    SLIT-ROBO Rho GTPase activating protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050420-284
    See related
    Ensembl:ENSDARG00000007461 AllianceGenome:ZFIN:ZDB-GENE-050420-284
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    srgap1; si:ch211-238a12.4
    Summary
    Predicted to be involved in negative regulation of cell migration. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in thyroid gland papillary carcinoma. Orthologous to human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See srgap1a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (12862748..13057237, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (12898764..13088959, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1 (platelet) Neighboring gene uncharacterized LOC110438085 Neighboring gene poly (ADP-ribose) polymerase family, member 12a Neighboring gene uncharacterized LOC108179959 Neighboring gene ribitol xylosyltransferase 1 Neighboring gene uncharacterized LOC100150699 Neighboring gene zgc:112052 Neighboring gene gigaxonin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Eumetazoan cryptochrome phylogeny and evolution. Haug MF, et al. Genome Biol Evol, 2015 Jan 18. PMID 25601102, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SLIT-ROBO Rho GTPase-activating protein 1; SLIT-ROBO Rho GTPase-activating protein 2B
    Names
    SLIT-ROBO Rho GTPase activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      12862748..13057237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352031.3 → XP_017207520.1  SLIT-ROBO Rho GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YU95, F1Q4Y5
      Related
      ENSDARP00000083341.4, ENSDART00000088908.7

    2. XM_017352030.3 → XP_017207519.1  SLIT-ROBO Rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z228
      Related
      ENSDARP00000120803.1, ENSDART00000140403.3

    3. XM_017352032.3 → XP_017207521.1  SLIT-ROBO Rho GTPase-activating protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YW41

    4. XM_017352033.3 → XP_017207522.1  SLIT-ROBO Rho GTPase-activating protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YW41

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395011.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      4701..94888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473245.2 → XP_021328920.1  SLIT-ROBO Rho GTPase-activating protein 2B isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q6U7
      Conserved Domains (1) summary
      cl12013
      Location:30 → 168
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version

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