U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    lzts1 leucine zipper, putative tumor suppressor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 569281, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lzts1provided by ZNC
    Official Full Name
    leucine zipper, putative tumor suppressor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-431
    See related
    Ensembl:ENSDARG00000075565 AllianceGenome:ZFIN:ZDB-GENE-081104-431
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-63d15.13
    Summary
    Predicted to be involved in regulation of dendrite morphogenesis and regulation of synaptic plasticity. Predicted to be located in cytoplasm. Predicted to be active in dendritic spine. Is expressed in female organism. Human ortholog(s) of this gene implicated in breast carcinoma; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lzts1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (39511972..39578254)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (39524727..39544544)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496302 Neighboring gene uncharacterized LOC137496376 Neighboring gene uncharacterized LOC137496377 Neighboring gene si:dkey-63d15.12 Neighboring gene musashi RNA binding protein 1b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of possible downstream genes required for the extension of peripheral axons in primary sensory neurons. Aoki M, et al. Biochem Biophys Res Commun, 2014 Mar 7. PMID 24513284
    2. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Armant O, et al. Dev Biol, 2013 Aug 15. PMID 23684812, Free PMC Article
    3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    leucine zipper putative tumor suppressor 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      39511972..39578254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009304165.4 → XP_009302440.1  leucine zipper putative tumor suppressor 1

      See identical proteins and their annotated locations for XP_009302440.1

      UniProtKB/TrEMBL
      A0A8N7TFD8, F1QXP6
      Related
      ENSDARP00000102219.4, ENSDART00000113511.4
      Conserved Domains (1) summary
      pfam06818
      Location:449 → 680
      Fez1; Fez1

    2. XM_692658.10 → XP_697750.3  leucine zipper putative tumor suppressor 1

      See identical proteins and their annotated locations for XP_697750.3

      UniProtKB/TrEMBL
      A0A8N7TFD8, F1QXP6
      Conserved Domains (1) summary
      pfam06818
      Location:449 → 680
      Fez1; Fez1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials