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    rasgrf1 Ras protein specific guanine nucleotide releasing factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 568885, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rasgrf1provided by ZNC
    Official Full Name
    Ras protein specific guanine nucleotide releasing factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090311-28
    See related
    Ensembl:ENSDARG00000073824 AllianceGenome:ZFIN:ZDB-GENE-090311-28
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-234p18.3
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rasgrf1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (26337896..26420860)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (26353346..26434365)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene microRNA 184 Neighboring gene antifreeze protein Maxi-like Neighboring gene cathepsin H Neighboring gene BLM RecQ like helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Prendergast AE, et al. Curr Biol, 2023 Mar 13. PMID 36791723
    2. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-specific guanine nucleotide-releasing factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      26337896..26420860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293629.4 → XP_009291904.1  ras-specific guanine nucleotide-releasing factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B2X9
      Conserved Domains (7) summary
      smart00147
      Location:1024 → 1261
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00325
      Location:244 → 425
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13261
      Location:19 → 154
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:24 → 129
      PH; PH domain
      pfam00618
      Location:643 → 691
      RasGEF_N; RasGEF N-terminal motif
      cl02520
      Location:928 → 997
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cl17171
      Location:474 → 596
      PH-like; Pleckstrin homology-like domain

    2. XM_002665349.6 → XP_002665395.1  ras-specific guanine nucleotide-releasing factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M1RKU8, E7F7V2
      Related
      ENSDARP00000103571.3, ENSDART00000109257.5
      Conserved Domains (7) summary
      smart00147
      Location:1017 → 1254
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00325
      Location:244 → 425
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13261
      Location:19 → 154
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:24 → 129
      PH; PH domain
      pfam00618
      Location:636 → 684
      RasGEF_N; RasGEF N-terminal motif
      cl02520
      Location:921 → 990
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cl17171
      Location:431 → 584
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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