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    eif4g3b eukaryotic translation initiation factor 4 gamma, 3b [ Danio rerio (zebrafish) ]

    Gene ID: 568761, updated on 2-Nov-2024

    Summary

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    Official Symbol
    eif4g3bprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 4 gamma, 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090312-49
    See related
    Ensembl:ENSDARG00000074331 AllianceGenome:ZFIN:ZDB-GENE-090312-49
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eif4g3; si:dkey-1a7.2
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Orthologous to human EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eif4g3b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (21978390..22060320)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (22051660..22134103)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene eph receptor B2a Neighboring gene uncharacterized LOC103909685 Neighboring gene lactamase, beta-like 1a Neighboring gene polyhomeotic homolog 2a (Drosophila) Neighboring gene solute carrier family 2 member 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish genes encoding the Polycomb repressive complex (PRC) 1. Le Faou P, et al. Gene, 2011 Apr 1. PMID 21195142
    2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 3; eukaryotic translation initiation factor 4 gamma, 3b
    Names
    eukaryotic translation initiation factor 4 gamma, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      21978390..22060320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296897.4 → XP_009295172.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AMY9
      Conserved Domains (5) summary
      cd11559
      Location:1552 → 1687
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1354 → 1465
      MA3; MA3 domain
      pfam02854
      Location:886 → 1114
      MIF4G; MIF4G domain
      pfam12067
      Location:230 → 312
      Sox_C_TAD; Sox C-terminal transactivation domain
      cl17013
      Location:1666 → 1712
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    2. XM_009296899.4 → XP_009295174.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M3B668
      Conserved Domains (5) summary
      cd11559
      Location:1551 → 1686
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1353 → 1464
      MA3; MA3 domain
      pfam02854
      Location:885 → 1113
      MIF4G; MIF4G domain
      pfam12067
      Location:230 → 312
      Sox_C_TAD; Sox C-terminal transactivation domain
      cl17013
      Location:1665 → 1711
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    3. XM_021469954.2 → XP_021325629.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PL50
      Conserved Domains (5) summary
      cd11559
      Location:1568 → 1703
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1370 → 1481
      MA3; MA3 domain
      pfam02854
      Location:902 → 1130
      MIF4G; MIF4G domain
      cl17013
      Location:1682 → 1728
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
      cl26464
      Location:59 → 631
      Atrophin-1; Atrophin-1 family

    4. XM_068216902.1 → XP_068073003.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

      Related
      ENSDARP00000113926.2, ENSDART00000145172.3

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395145.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      448614..521358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473665.2 → XP_021329340.2  eukaryotic translation initiation factor 4 gamma 3 isoform X5

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395362.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      140870..221237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474541.2 → XP_021330216.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q5C1
      Conserved Domains (6) summary
      cd11559
      Location:1569 → 1704
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1371 → 1482
      MA3; MA3 domain
      pfam02854
      Location:903 → 1131
      MIF4G; MIF4G domain
      cl17013
      Location:1683 → 1729
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
      cl25574
      Location:1094 → 1371
      TOP2c; TopoisomeraseII
      cl26464
      Location:59 → 632
      Atrophin-1; Atrophin-1 family

    2. XM_021474545.2 → XP_021330220.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QA56
      Conserved Domains (6) summary
      cd11559
      Location:1552 → 1687
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1354 → 1465
      MA3; MA3 domain
      pfam02854
      Location:886 → 1114
      MIF4G; MIF4G domain
      cl17013
      Location:1666 → 1712
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
      cl25574
      Location:1077 → 1354
      TOP2c; TopoisomeraseII
      cl26464
      Location:59 → 615
      Atrophin-1; Atrophin-1 family

    3. XM_021474546.2 → XP_021330221.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q5C3
      Conserved Domains (6) summary
      cd11559
      Location:1551 → 1686
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1353 → 1464
      MA3; MA3 domain
      pfam02854
      Location:885 → 1113
      MIF4G; MIF4G domain
      cl17013
      Location:1665 → 1711
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
      cl25574
      Location:1076 → 1353
      TOP2c; TopoisomeraseII
      cl26464
      Location:57 → 666
      Atrophin-1; Atrophin-1 family

    4. XM_021474542.2 → XP_021330217.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PG53
      Conserved Domains (6) summary
      cd11559
      Location:1568 → 1703
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1370 → 1481
      MA3; MA3 domain
      pfam02854
      Location:902 → 1130
      MIF4G; MIF4G domain
      cl17013
      Location:1682 → 1728
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
      cl25574
      Location:1093 → 1370
      TOP2c; TopoisomeraseII
      cl26464
      Location:59 → 631
      Atrophin-1; Atrophin-1 family

    5. XM_021474543.2 → XP_021330218.1  eukaryotic translation initiation factor 4 gamma 3 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PT74
      Conserved Domains (6) summary
      cd11559
      Location:1562 → 1697
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1364 → 1475
      MA3; MA3 domain
      pfam02854
      Location:896 → 1124
      MIF4G; MIF4G domain
      cl17013
      Location:1676 → 1722
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
      cl25574
      Location:1087 → 1364
      TOP2c; TopoisomeraseII
      cl26464
      Location:59 → 625
      Atrophin-1; Atrophin-1 family

    6. XM_068219396.1 → XP_068075497.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

    7. XM_021474544.2 → XP_021330219.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PZ68
      Conserved Domains (6) summary
      cd11559
      Location:1561 → 1696
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1363 → 1474
      MA3; MA3 domain
      pfam02854
      Location:895 → 1123
      MIF4G; MIF4G domain
      cl17013
      Location:1675 → 1721
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
      cl25574
      Location:1086 → 1363
      TOP2c; TopoisomeraseII
      cl26464
      Location:51 → 624
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

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