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    kmt2cb lysine (K)-specific methyltransferase 2Cb [ Danio rerio (zebrafish) ]

    Gene ID: 568162, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kmt2cbprovided by ZNC
    Official Full Name
    lysine (K)-specific methyltransferase 2Cbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-340
    See related
    Ensembl:ENSDARG00000075560 AllianceGenome:ZFIN:ZDB-GENE-070705-340
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mll3b; si:dkey-193e13.2
    Summary
    Predicted to enable histone H3K4 methyltransferase activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization and regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Human ortholog(s) of this gene implicated in Kleefstra syndrome 2; carcinoma (multiple); and stomach cancer. Orthologous to human KMT2C (lysine methyltransferase 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See kmt2cb in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (12847631..13037545)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (13164838..13354754)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 21b Neighboring gene dipeptidyl-peptidase 6b Neighboring gene protein kinase, AMP-activated, gamma 2 non-catalytic subunit b Neighboring gene BCL2 apoptosis regulator b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study of kidney function decline in individuals of European descent. Gorski M, et al. Kidney Int, 2015 May. PMID 25493955, Free PMC Article
    2. The DEAD-box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Zhang L, et al. Development, 2018 Apr 23. PMID 29636379
    3. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. Sun XJ, et al. PLoS One, 2008 Jan 30. PMID 18231586, Free PMC Article
    4. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Fellous A, et al. Gene, 2019 Mar 1. PMID 30458291
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein-containing complex organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2C
    Names
    myeloid/lymphoid or mixed-lineage leukemia 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      12847631..13037545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009298109.4 → XP_009296384.1  histone-lysine N-methyltransferase 2C isoform X1

      UniProtKB/TrEMBL
      A0A8M3B7B2
      Conserved Domains (12) summary
      smart00398
      Location:1691 → 1744
      HMG; high mobility group
      smart00317
      Location:4753 → 4868
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:4877 → 4892
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam09606
      Location:3255 → 3659
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15509
      Location:332 → 377
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:459 → 507
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:379 → 424
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      pfam05964
      Location:4536 → 4586
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4594 → 4673
      FYRC; F/Y rich C-terminus
      pfam13863
      Location:3168 → 3262
      DUF4200; Domain of unknown function (DUF4200)
      cl22851
      Location:4379 → 4483
      PHD_SF; PHD finger superfamily

    2. XM_017351380.3 → XP_017206869.1  histone-lysine N-methyltransferase 2C isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z161

    3. XM_005163297.5 → XP_005163354.1  histone-lysine N-methyltransferase 2C isoform X5

      UniProtKB/TrEMBL
      A0A8M2BAH2
      Related
      ENSDARP00000122949.2, ENSDART00000131780.3
      Conserved Domains (12) summary
      smart00398
      Location:1691 → 1744
      HMG; high mobility group
      smart00317
      Location:4741 → 4856
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:4865 → 4880
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam09606
      Location:3243 → 3647
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15509
      Location:332 → 377
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:459 → 507
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:379 → 424
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      pfam05964
      Location:4524 → 4574
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4582 → 4661
      FYRC; F/Y rich C-terminus
      pfam13863
      Location:3156 → 3250
      DUF4200; Domain of unknown function (DUF4200)
      cl22851
      Location:4367 → 4471
      PHD_SF; PHD finger superfamily

    4. XM_009298114.4 → XP_009296389.1  histone-lysine N-methyltransferase 2C isoform X6

      UniProtKB/TrEMBL
      A0A8M3APU4
      Conserved Domains (12) summary
      smart00398
      Location:1675 → 1728
      HMG; high mobility group
      smart00317
      Location:4737 → 4852
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:4861 → 4876
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam09606
      Location:3239 → 3643
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15509
      Location:332 → 377
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:459 → 507
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:379 → 424
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      pfam05964
      Location:4520 → 4570
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4578 → 4657
      FYRC; F/Y rich C-terminus
      pfam13863
      Location:3152 → 3246
      DUF4200; Domain of unknown function (DUF4200)
      cl22851
      Location:4363 → 4467
      PHD_SF; PHD finger superfamily

    5. XM_009298123.4 → XP_009296398.1  histone-lysine N-methyltransferase 2C isoform X9

      UniProtKB/TrEMBL
      A0A8M3AP79
      Conserved Domains (12) summary
      smart00398
      Location:1640 → 1693
      HMG; high mobility group
      smart00317
      Location:4702 → 4817
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:4826 → 4841
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam09606
      Location:3204 → 3608
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15509
      Location:332 → 377
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:459 → 507
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:379 → 424
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      pfam05964
      Location:4485 → 4535
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4543 → 4622
      FYRC; F/Y rich C-terminus
      pfam13863
      Location:3117 → 3211
      DUF4200; Domain of unknown function (DUF4200)
      cl22851
      Location:4328 → 4432
      PHD_SF; PHD finger superfamily

    6. XM_017351382.3 → XP_017206871.1  histone-lysine N-methyltransferase 2C isoform X3

      UniProtKB/TrEMBL
      A0A8M6YVA2

    7. XM_005163294.5 → XP_005163351.1  histone-lysine N-methyltransferase 2C isoform X2

      UniProtKB/TrEMBL
      A0A8M2BAF3
      Conserved Domains (12) summary
      smart00398
      Location:1690 → 1743
      HMG; high mobility group
      smart00317
      Location:4752 → 4867
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:4876 → 4891
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam09606
      Location:3254 → 3658
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15509
      Location:332 → 377
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:459 → 507
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1003 → 1049
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:379 → 424
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      pfam05964
      Location:4535 → 4585
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4593 → 4672
      FYRC; F/Y rich C-terminus
      pfam13863
      Location:3167 → 3261
      DUF4200; Domain of unknown function (DUF4200)
      cl22851
      Location:4378 → 4482
      PHD_SF; PHD finger superfamily

    8. XM_068213615.1 → XP_068069716.1  histone-lysine N-methyltransferase 2C isoform X10

    9. XM_009298120.4 → XP_009296395.1  histone-lysine N-methyltransferase 2C isoform X7

      UniProtKB/TrEMBL
      A0A8M3AWQ1
      Conserved Domains (12) summary
      smart00398
      Location:1653 → 1706
      HMG; high mobility group
      smart00317
      Location:4715 → 4830
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:4839 → 4854
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam09606
      Location:3217 → 3621
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15509
      Location:332 → 377
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:459 → 507
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:966 → 1012
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:379 → 424
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      pfam05964
      Location:4498 → 4548
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4556 → 4635
      FYRC; F/Y rich C-terminus
      pfam13863
      Location:3130 → 3224
      DUF4200; Domain of unknown function (DUF4200)
      cl22851
      Location:4341 → 4445
      PHD_SF; PHD finger superfamily

    10. XM_017351393.3 → XP_017206882.1  histone-lysine N-methyltransferase 2C isoform X8

      UniProtKB/TrEMBL
      A0A8M6Z169
    Nucleotide Protein Strain
    Heading Accession and Version

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