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    dnali1 dynein, axonemal, light intermediate chain 1 [ Danio rerio (zebrafish) ]

    Gene ID: 567632, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dnali1provided by ZNC
    Official Full Name
    dynein, axonemal, light intermediate chain 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-7
    See related
    Ensembl:ENSDARG00000069815 AllianceGenome:ZFIN:ZDB-GENE-080204-7
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:171493; zgc:171595
    Summary
    Predicted to enable dynein heavy chain binding activity. Predicted to be active in axoneme and ciliary base. Human ortholog(s) of this gene implicated in spermatogenic failure 83. Orthologous to human DNALI1 (dynein axonemal light intermediate chain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dnali1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (33925746..33930080, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (33971716..33976050, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene R-spondin 1 Neighboring gene uncharacterized LOC137487930 Neighboring gene G protein nucleolar 2 Neighboring gene Smad nuclear interacting protein Neighboring gene GPN-loop GTPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes. Wang Y, et al. Front Cell Dev Biol, 2020. PMID 33251213, Free PMC Article
    2. Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Gallagher TL, et al. Dev Biol, 2017 Sep 1. PMID 28648842, Free PMC Article
    3. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC171493, MGC171595

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary base IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    axonemal dynein light intermediate polypeptide 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110114.2 → NP_001103584.2  axonemal dynein light intermediate polypeptide 1

      Status: VALIDATED

      Source sequence(s)
      BX649265
      UniProtKB/TrEMBL
      A0A8M1NF38, F1Q6H8
      Related
      ENSDARP00000092673.5, ENSDART00000101898.7
      Conserved Domains (1) summary
      pfam10211
      Location:63 → 249
      Ax_dynein_light; Axonemal dynein light chain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      33925746..33930080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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