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    phf21ab PHD finger protein 21Ab [ Danio rerio (zebrafish) ]

    Gene ID: 565544, updated on 2-Nov-2024

    Summary

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    Official Symbol
    phf21abprovided by ZNC
    Official Full Name
    PHD finger protein 21Abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6456
    See related
    Ensembl:ENSDARG00000021378 AllianceGenome:ZFIN:ZDB-GENE-030131-6456
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    phf21a; fj98d03; wu:fj98d03
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within face development. Predicted to be part of histone deacetylase complex. Is expressed in central nervous system; head; optic cup; otic vesicle; and pectoral fin. Orthologous to human PHF21A (PHD finger protein 21A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See phf21ab in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (7718550..7768403, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (7591895..7639503, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene CD59 molecule (CD59 blood group) b Neighboring gene PR domain containing 11 Neighboring gene diacylglycerol kinase, zeta b Neighboring gene midkine b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies. Kim HG, et al. Am J Hum Genet, 2012 Jul 13. PMID 22770980, Free PMC Article
    2. Neural differentiation modulates the vertebrate brain specific splicing program. Madgwick A, et al. PLoS One, 2015. PMID 25993117, Free PMC Article
    3. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
    4. Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Zhang J, et al. Front Endocrinol (Lausanne), 2018. PMID 30631305, Free PMC Article
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within face development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 21A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      7718550..7768403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217492.1 → XP_068073593.1  PHD finger protein 21A isoform X9

      Related
      ENSDARP00000150633.1, ENSDART00000179800.1

    2. XM_688823.8 → XP_693915.3  PHD finger protein 21A isoform X9

      See identical proteins and their annotated locations for XP_693915.3

      UniProtKB/TrEMBL
      A0A2R8QB31, A0A8N7TF35
      Related
      ENSDARP00000019987.9, ENSDART00000021577.11
      Conserved Domains (2) summary
      cd15523
      Location:464 → 506
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:1 → 61
      STAT_alpha; STAT protein, all-alpha domain

    3. XM_068217489.1 → XP_068073590.1  PHD finger protein 21A isoform X7

    4. XM_005174283.5 → XP_005174340.1  PHD finger protein 21A isoform X7

      See identical proteins and their annotated locations for XP_005174340.1

      UniProtKB/TrEMBL
      A0A2R8RUQ1, A0A8M9PN25
      Related
      ENSDARP00000153243.1, ENSDART00000181858.1
      Conserved Domains (2) summary
      cd15523
      Location:495 → 537
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:1 → 61
      STAT_alpha; STAT protein, all-alpha domain

    5. XM_005174280.5 → XP_005174337.1  PHD finger protein 21A isoform X7

      See identical proteins and their annotated locations for XP_005174337.1

      UniProtKB/TrEMBL
      A0A2R8RUQ1, A0A8M9PN25
      Conserved Domains (2) summary
      cd15523
      Location:495 → 537
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:1 → 61
      STAT_alpha; STAT protein, all-alpha domain

    6. XM_068217491.1 → XP_068073592.1  PHD finger protein 21A isoform X8

      Related
      ENSDARP00000111141.3, ENSDART00000126499.3

    7. XM_068217490.1 → XP_068073591.1  PHD finger protein 21A isoform X7

    8. XM_068217493.1 → XP_068073594.1  PHD finger protein 21A isoform X8

    9. XM_005174282.5 → XP_005174339.1  PHD finger protein 21A isoform X7

      See identical proteins and their annotated locations for XP_005174339.1

      UniProtKB/TrEMBL
      A0A2R8RUQ1, A0A8M9PN25
      Conserved Domains (2) summary
      cd15523
      Location:495 → 537
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:1 → 61
      STAT_alpha; STAT protein, all-alpha domain

    10. XM_021470619.2 → XP_021326294.1  PHD finger protein 21A isoform X7

      UniProtKB/TrEMBL
      A0A2R8RUQ1, A0A8M9PN25
      Conserved Domains (2) summary
      cd15523
      Location:495 → 537
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:1 → 61
      STAT_alpha; STAT protein, all-alpha domain

    11. XM_021470615.2 → XP_021326290.1  PHD finger protein 21A isoform X2

      UniProtKB/TrEMBL
      A0A8M9PYT2
      Conserved Domains (3) summary
      cd15523
      Location:558 → 600
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:64 → 125
      STAT_alpha; STAT protein, all-alpha domain
      cl25495
      Location:137 → 270
      Endomucin

    12. XM_068217488.1 → XP_068073589.1  PHD finger protein 21A isoform X4

    13. XM_021470614.2 → XP_021326289.1  PHD finger protein 21A isoform X1

      UniProtKB/TrEMBL
      A0A8M9PN21
      Conserved Domains (2) summary
      cd15523
      Location:559 → 601
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:64 → 125
      STAT_alpha; STAT protein, all-alpha domain

    14. XM_021470618.2 → XP_021326293.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      A0A8M9PH61
      Conserved Domains (3) summary
      cd15523
      Location:500 → 542
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:64 → 125
      STAT_alpha; STAT protein, all-alpha domain
      cl26267
      Location:447 → 545
      ING; Inhibitor of growth proteins N-terminal histone-binding

    15. XM_021470617.2 → XP_021326292.1  PHD finger protein 21A isoform X5

      UniProtKB/TrEMBL
      A0A8M9P6P2
      Conserved Domains (1) summary
      pfam01017
      Location:64 → 125
      STAT_alpha; STAT protein, all-alpha domain

    16. XM_021470616.2 → XP_021326291.1  PHD finger protein 21A isoform X3

      UniProtKB/TrEMBL
      A0A8M9PVB7
      Conserved Domains (2) summary
      cd15523
      Location:528 → 570
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:64 → 125
      STAT_alpha; STAT protein, all-alpha domain

    17. XM_021470620.2 → XP_021326295.1  PHD finger protein 21A isoform X10

      UniProtKB/TrEMBL
      A0A8M9PYT7
      Conserved Domains (1) summary
      pfam01017
      Location:64 → 125
      STAT_alpha; STAT protein, all-alpha domain
    Nucleotide Protein Strain
    Heading Accession and Version

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