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    acap2a ArfGAP with coiled-coil, ankyrin repeat and PH domains 2a [ Danio rerio (zebrafish) ]

    Gene ID: 564814, updated on 2-Nov-2024

    Summary

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    Official Symbol
    acap2aprovided by ZNC
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-34
    See related
    Ensembl:ENSDARG00000056478 AllianceGenome:ZFIN:ZDB-GENE-081104-34
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-168b3.1
    Summary
    Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be located in endosome membrane. Orthologous to human ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See acap2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (5887630..5926562)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (5975751..6012333)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene mesoderm induction early response 1b, transcriptional regulator Neighboring gene DIS3 like 3'-5' exoribonuclease 2 Neighboring gene transmembrane protein 125b Neighboring gene solute carrier family 1 member 7a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      5887630..5926562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163249.5 → XP_005163306.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAD9, B8JLA1
      Related
      ENSDARP00000121563.2, ENSDART00000147831.3
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd00204
      Location:658 → 776
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:273 → 369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:273 → 365
      PH; PH domain
      pfam01412
      Location:402 → 520
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:660 → 754
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:657 → 686
      ANK; ANK repeat [structural motif]

    2. XM_009297237.4 → XP_009295512.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AVV3
      Related
      ENSDARP00000156920.1, ENSDART00000188119.1
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd00204
      Location:657 → 775
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:273 → 369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:273 → 365
      PH; PH domain
      pfam01412
      Location:402 → 520
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:659 → 753
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:656 → 685
      ANK; ANK repeat [structural motif]

    3. XM_068213489.1 → XP_068069590.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

    4. XM_068213490.1 → XP_068069591.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version

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