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    slc26a3.2 solute carrier family 26 member 3, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 563896, updated on 2-Nov-2024

    Summary

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    Official Symbol
    slc26a3.2provided by ZNC
    Official Full Name
    solute carrier family 26 member 3, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-179
    See related
    Ensembl:ENSDARG00000003615 AllianceGenome:ZFIN:ZDB-GENE-041210-179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136981; si:dkey-31f5.1
    Summary
    Predicted to enable inorganic anion transmembrane transporter activity and organic anion transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport and sulfate transmembrane transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital secretory chloride diarrhea 1 and diarrhea. Orthologous to human SLC26A3 (solute carrier family 26 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See slc26a3.2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18799208..18823032)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18810186..18834056)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene DEF6 guanine nucleotide exchange factor c Neighboring gene solute carrier family 26 member 4 Neighboring gene uncharacterized LOC110439361 Neighboring gene uncharacterized LOC137491543 Neighboring gene uncharacterized LOC110439362 Neighboring gene solute carrier family 26 member 3 Neighboring gene Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish. Liu F, et al. PLoS One, 2015. PMID 26375458, Free PMC Article
    2. Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity. Aceto J, et al. PLoS One, 2015. PMID 26061167, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC136981

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 26 member 3, tandem duplicate 2
    Names
    solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040175.1 → NP_001035265.1  solute carrier family 26 member 3, tandem duplicate 2

      See identical proteins and their annotated locations for NP_001035265.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115355
      UniProtKB/TrEMBL
      A0A8M1N8V8, Q1RLN9
      Related
      ENSDARP00000091817.2, ENSDART00000101043.5
      Conserved Domains (2) summary
      cd07042
      Location:517 → 701
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:59 → 705
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      18799208..18823032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164755.5 → XP_005164812.1  solute carrier family 26 member 3, tandem duplicate 2 isoform X1

      See identical proteins and their annotated locations for XP_005164812.1

      UniProtKB/TrEMBL
      A0A8M1N8V8, Q1RLN9
      Conserved Domains (2) summary
      cd07042
      Location:517 → 701
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:59 → 705
      sulP; high affinity sulphate transporter 1
    Nucleotide Protein
    Heading Accession and Version

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