sgsh N-sulfoglucosamine sulfohydrolase (sulfamidase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sgshprovided by ZNC
Official Full Name: N-sulfoglucosamine sulfohydrolase (sulfamidase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4958
See related: Ensembl:ENSDARG00000032087 AllianceGenome:ZFIN:ZDB-GENE-030131-4958
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fe14h11
Summary: Enables N-sulfoglucosamine sulfohydrolase activity. Involved in heparan sulfate proteoglycan catabolic process. Acts upstream of or within locomotory behavior; microglial cell activation; and thigmotaxis. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (11520249..11532760)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (11490567..11503078)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-sulfoglucosamine sulfohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-sulfoglucosamine sulfohydrolase activity	IEA Inferred from Electronic Annotation more info
enables N-sulfoglucosamine sulfohydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycosaminoglycan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: N-sulphoglucosamine sulphohydrolase

NP_001116740.1

EC 3.10.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123268.1 → NP_001116740.1 N-sulphoglucosamine sulphohydrolase precursor

Status: PROVISIONAL

Source sequence(s)

CU459096

UniProtKB/TrEMBL

A0A8M1NG51, B0V3V9

Related

ENSDARP00000063146.4, ENSDART00000063147.5

Conserved Domains (2) summary

COG3119
Location:25 → 461

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

cd16027
Location:25 → 481

SGSH; N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)