enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: enpp1provided by ZNC
Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-172
See related: Ensembl:ENSDARG00000005789 AllianceGenome:ZFIN:ZDB-GENE-040724-172
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136238; si:ch211-142e24.2
Summary: Predicted to enable dinucleotide phosphatase activity and phosphodiesterase I activity. Acts upstream of or within phosphate ion homeostasis and regulation of bone mineralization. Predicted to be located in extracellular region and membrane. Predicted to be active in cell surface. Is expressed in cleithrum and opercle. Used to study arterial calcification of infancy and pseudoxanthoma elasticum. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (13403276..13521014)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (13507257..13625034)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

enpp1 can exert its function in tissues that are remote from its site of expression.
Title: Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE).

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dinucleotide phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables phosphodiesterase I activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inorganic diphosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside triphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Names: dgf

NP_001025339.1

EC 3.1.4.1

EC 3.6.1.9

XP_005160498.1

EC 3.1.4.1

EC 3.6.1.9

XP_009292877.1

EC 3.1.4.1

EC 3.6.1.9

XP_021324146.1

EC 3.1.4.1

EC 3.6.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030168.1 → NP_001025339.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Status: PROVISIONAL

Source sequence(s)

BX293547

UniProtKB/TrEMBL

A0A8M1N7G9

Conserved Domains (5) summary

smart00201
Location:112 → 155

SO; Somatomedin B -like domains

pfam01033
Location:70 → 108

Somatomedin_B; Somatomedin B domain

pfam01663
Location:179 → 505

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:177 → 545

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

cl00089
Location:642 → 860

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

13403276..13521014

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160441.5 → XP_005160498.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1

See identical proteins and their annotated locations for XP_005160498.1

UniProtKB/TrEMBL

A0A8M2B797, B0JZL7, Q5RI82

Related

ENSDARP00000112341.3, ENSDART00000127350.4

Conserved Domains (5) summary

smart00201
Location:112 → 155

SO; Somatomedin B -like domains

pfam01033
Location:70 → 108

Somatomedin_B; Somatomedin B domain

pfam01663
Location:179 → 505

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:177 → 545

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

cl00089
Location:644 → 862

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
XM_009294602.4 → XP_009292877.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X2

UniProtKB/TrEMBL

A0A8M3B403

Conserved Domains (4) summary

pfam01033
Location:70 → 108

Somatomedin_B; Somatomedin B domain

pfam01663
Location:137 → 463

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:135 → 503

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

cl00089
Location:602 → 820

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
XM_021468471.2 → XP_021324146.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X3

UniProtKB/TrEMBL

A0A8M9PPG3

Conserved Domains (4) summary

smart00201
Location:112 → 155

SO; Somatomedin B -like domains

pfam01033
Location:70 → 108

Somatomedin_B; Somatomedin B domain

pfam01663
Location:179 → 505

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cl00089
Location:644 → 740

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.