igf3 insulin-like growth factor 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igf3provided by ZNC
Official Full Name: insulin-like growth factor 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-080611-1
See related: Ensembl:ENSDARG00000058058 AllianceGenome:ZFIN:ZDB-GENE-080611-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IGF-3
Summary: Enables insulin-like growth factor receptor binding activity. Acts upstream of or within oocyte maturation and sperm capacitation. Predicted to be located in extracellular space. Is expressed in several structures, including gill; gonad; head; kidney; and muscle. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (13978555..13985032, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (13940850..13947327, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that an important aspect of Fsh bioactivity in stimulating spermatogenesis is implemented by restricting the different inhibitory effects of Amh and by counterbalancing them with stimulatory signals, such as Igf3.
Title: Antagonistic regulation of spermatogonial differentiation in zebrafish (Danio rerio) by Igf3 and Amh.
expression in wild-type gills in addition to gonads
Title: Expression of KRASG12V in Zebrafish Gills Induces Hyperplasia and CXCL8-Associated Inflammation.
Data show that in testis tissue culture only insulin-like growth factor 3 (igf3) transcript levels increased in response to recombinant follicle stimulating hormone.
Title: Fsh Stimulates Spermatogonial Proliferation and Differentiation in Zebrafish via Igf3.
An important role of Igf3 in the ovarian functions of zebrafish, especially in oocyte maturation.
Title: Insulin-like growth factor 3 is involved in oocyte maturation in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 3

Names: igf1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.