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    esrp1 epithelial splicing regulatory protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 560190, updated on 12-Sep-2024

    Summary

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    Official Symbol
    esrp1provided by ZNC
    Official Full Name
    epithelial splicing regulatory protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-1732
    See related
    Ensembl:ENSDARG00000011245 AllianceGenome:ZFIN:ZDB-GENE-070112-1732
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rbm35a; wu:fi28a07; zgc:154050
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including digestive system; ectoderm; epidermis; median fin fold; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See esrp1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (26645663..26676684, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (26772213..26803294, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 3 Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene uncharacterized LOC137487907 Neighboring gene vir like m6A methyltransferase associated Neighboring gene ring finger protein 41, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Warzecha CC, et al. Mol Cell, 2009 Mar 13. PMID 19285943, Free PMC Article
    2. Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule. Sugano Y, et al. Pflugers Arch, 2017 Aug. PMID 28656378
    3. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
    4. An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Carroll SH, et al. Development, 2020 Dec 23. PMID 33234718, Free PMC Article
    5. A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Melvin VS, et al. Dev Dyn, 2013 Jul. PMID 23559552, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cranial skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hard palate morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epithelial splicing regulatory protein 1
    Names
    RNA-binding motif protein 35A
    RNA-binding protein 35A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080576.1 → NP_001074045.1  epithelial splicing regulatory protein 1

      Status: PROVISIONAL

      Source sequence(s)
      BC129044
      UniProtKB/Swiss-Prot
      A1L1G1, A4FVM7
      Related
      ENSDARP00000094207.3, ENSDART00000103431.4
      Conserved Domains (5) summary
      COG0724
      Location:272 → 502
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12736
      Location:221 → 305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:449 → 529
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:7 → 174
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:310 → 416
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      26645663..26676684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213978.1 → XP_068070079.1  epithelial splicing regulatory protein 1 isoform X2

    2. XM_005158027.5 → XP_005158084.1  epithelial splicing regulatory protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B4A5
      Conserved Domains (5) summary
      COG0724
      Location:272 → 502
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12736
      Location:221 → 305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:449 → 529
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:7 → 174
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:310 → 416
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L1G1.1 GenPept UniProtKB/Swiss-Prot:A1L1G1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.