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    prmt2 protein arginine methyltransferase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558841, updated on 2-Nov-2024

    Summary

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    Official Symbol
    prmt2provided by ZNC
    Official Full Name
    protein arginine methyltransferase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041104-1
    See related
    Ensembl:ENSDARG00000063212 AllianceGenome:ZFIN:ZDB-GENE-041104-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hrmt1l1; zgc:158247; si:ch211-226c11.1
    Summary
    Enables identical protein binding activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to act upstream of or within peptidyl-arginine methylation. Predicted to be active in nucleus. Orthologous to human PRMT2 (protein arginine methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See prmt2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (9953063..9961000, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (9981690..9989627, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene follistatin-like 1b Neighboring gene uncharacterized LOC137496420 Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase 1 family a, b Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A4 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7 Neighboring gene neurexophilin 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. Cura V, et al. FEBS J, 2017 Jan. PMID 27879050
    2. Zebrafish prmt2 Attenuates Antiviral Innate Immunity by Targeting traf6. Zhu J, et al. J Immunol, 2021 Nov 15. PMID 34654690
    3. Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians. Hung CM, et al. Gene, 2004 Oct 13. PMID 15475159
    4. Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Dong CW, et al. Fish Shellfish Immunol, 2007 Apr. PMID 17055744
    5. Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3. Haws W, et al. Sci Rep, 2023 Jan 20. PMID 36670152, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRMT2 is a modular protein containing a catalytic Ado-Met-binding domain and unique Src homology 3 domain that binds proteins with proline-rich motifs.
      Title: Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC158247

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidyl-arginine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein arginine N-methyltransferase 2
    Names
    HMT1 hnRNP methyltransferase-like 1
    NP_001073644.2
    XP_021334365.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080175.2 → NP_001073644.2  protein arginine N-methyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      AL954329, CT641169, EH521555
      UniProtKB/TrEMBL
      A0A8M1NCQ6, A1L1Q4, F1QDD1
      Related
      ENSDARP00000086597.3, ENSDART00000092164.4
      Conserved Domains (3) summary
      cd02440
      Location:119 → 216
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cd11806
      Location:14 → 66
      SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
      pfam05185
      Location:118 → 381
      PRMT5; PRMT5 arginine-N-methyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      9953063..9961000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478690.2 → XP_021334365.1  protein arginine N-methyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QJP4, A1L1Q4
      Conserved Domains (2) summary
      cd02440
      Location:60 → 157
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05185
      Location:59 → 322
      PRMT5; PRMT5 arginine-N-methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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